小剂量普瑞巴林在腹腔镜胆囊切除术中的应用被引量：4

Effect of low-dose pregabalin in patients undergoing laparoscopic cholecystectomy

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摘要目的评价小剂量普瑞巴林用于腹腔镜胆囊切除术(LC)患者中的镇痛效果。方法 180例于全麻下行LC患者随机分为安慰剂组(C组)、普瑞巴林50 mg组(P1组)与普瑞巴林75 mg组(P2组)。根据分组,术前给予普瑞巴林或安慰剂,观察术后疼痛评分及相关副作用的发生率。结果与安慰剂组相比,75 mg普瑞巴林组患者术后90 min疼痛评分明显降低(P<0.05),而50 mg普瑞巴林的镇痛作用仅维持至术后45 min(P<0.05)。各组术后副作用发生率未见明显差异。结论腹腔镜胆囊切除术前应用小剂量普瑞巴林可改善术后疼痛治疗的质量。 Objective To investigate the analgesic effect of low-dose pregabalin in patients undergoing laparoscopic cholecystectomy. Methods One hundred and eighty patients undergoing elective laparoscopic cholecystectomy were di- vided into placebo group （C group）, pregabalin 50mg group （P1 group） and pregabalin 75mg group （P2 group）. Before operation, patients received pregabalin or placebo orally. Postoperative pain scores, analgesic consumption, and sideeffects were recorded. Results Compared with the placebo group, the pain scores were lower in the pregabalin 75 mg group in the first 90 min after surgery （P〈0.05）, but the pain scores in the pregabalin 50mg were lower in 45 min after surgery（P〈0.05）. The side-effects were similar among the three groups. Conclusion Perioperative administration of lowdose pregabalin provided analgesic benefit in the postoperative period.

作者邱媛肖纯

机构地区浙江省嘉兴市妇幼保健院检验科浙江省嘉兴市第一医院麻醉科

出处《中国现代医生》 2014年第6期82-84,共3页 China Modern Doctor

基金浙江省医学会项目(2011ZYC-A77)

关键词胆囊切除术疼痛普瑞巴林术前用药 Cholecystectomy Pain Pregabalin Premedication

分类号 R657.42 [医药卫生—外科学]

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