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抑郁症首次发病维吾尔族、汉族患者血清白介素-2、6及其可溶性受体水平的对照研究 被引量:5

Control study of levels of serum interleukin-2,6 and its soluble receptor in Uygur and Han patients with first onset depression
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摘要 目的:探讨抑郁症首次发病的维吾尔族(维族)、汉族患者血清白介素(IL)-2、IL-6及其可溶性受体(sIL-2R、sIL-6R)水平的变化。方法:对117例首次发病的抑郁症患者(抑郁症组,维族亚组57例,汉族亚组60例)给予文拉法辛治疗4周。治疗前后采用汉密尔顿抑郁量表(HAMD)-17项评定病情,采用酶联免疫吸附法(ELISA)检测血清IL-2、IL-6及sIL-2R、sIL-6R水平;并与性别、年龄相匹配的正常对照组(维族、汉族各55例)比较。结果:抑郁症维族及汉族亚组HAMD评分治疗后较治疗前显著下降(P均<0.01),两亚组间差异无统计学意义。抑郁症组治疗前血清IL-2、IL-6及sIL-2R、sIL-6R水平明显高于正常对照组(P均<0.01),且IL-2、sIL-6R水平在维族与汉族亚组间差异有统计学意义(P均<0.01);治疗后血清IL-2、IL-6及sIL-2R、sIL-6R水平较治疗前明显下降(P均<0.01)。结论:维族和汉族抑郁症患者均有免疫失调;文拉法辛治疗能改善抑郁症病情及免疫失调。 Objective: To explore the changes of levels of serum interleukin (IL)-2,IL-6 and their soluble receptors (sIL-2R,sIL-6R) in Uygur and Han patients with first onset depression.Method:One hundred and seventeen first onset depressive patients (depression group,57 cases in the Uygur subgroup and 60 cases in the Han subgroup) were assessed by Hamilton depression rating scale-17 items (HAMD).The levels of serum IL-2,IL-6 and sIL-2R,sIL-6R were detected by Enzyme-linked immunosorbent assay (ELISA).The results were compared with the gender,age-matched normal control group (55 Uygurs and 55 Hans).Results:After treatment,the HAMD score was significantly decreased than before treatment in depression group (P<0.01);but the difference between the Uygur and the Han subgroups was not notable. Before treatment,the levels of serum IL-2,IL-6 and sIL-2R,sIL-6R in depression group were significantly higher than those in normal control group (all P<0.01);and the levels of serum IL-2,sIL-6R between the Uygur and the Han subgroups had significant difference (all P<0.01). After treatment,the levels of serum IL-2,IL-6 and sIL-2R,sIL-6R were decreased significantly(all P<0.01).Conclusion:The immunity dysregulation exists in both Han and Uygur depressive patients. Venlafaxine can improve the depressive condition and immunity dysregulation.
出处 《临床精神医学杂志》 2014年第1期17-20,共4页 Journal of Clinical Psychiatry
基金 新疆维吾尔自治区自然科学基金资助项目(2011211A081)
关键词 抑郁症 白介素-2 白介素-6 白介素可溶性受体-2 白介素可溶性受体-6 depression interleukin-2 interleukin-6 soluble interleukin-2 receptor soluble interleukin-6 receptor
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