摘要
目的研究美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的临床效果及安全性。方法将2011年6月～2013年9月本院收治的溃疡性结肠炎患者90例按治疗方法不同分为试验组47例（给予口服美沙拉嗪治疗）和对照组43例（给予口服柳氮磺吡啶治疗），比较两组治疗效果。结果治疗2个疗程后，试验组腹痛、黏液血便治疗总有效率明显高于对照组（P〈0．05），但两组腹泻症状治疗总有效率差异无统计学意义（P〉0．05）；治疗2个疗程后，试验组组织学积分低于对照组（P〈0．05）；对照组不良反应发生率高于试验组（P〈0．05）。结论美沙拉嗪治疗溃疡性结肠炎效果显著，其临床疗效及安全性均优于柳氮磺吡啶，值得临床推广应用。
Objective To compare the clinical efficacy and safety of mesalazine and sulfasalazine in treatment of ulcerative colitis.Methods 90 cases of patients with ulcerative colitis in our hospital from June 2011 to September 2013 were divided into experimental group （47 cases,given mesalazine）and control group （43 cases, given sulfasalazine）,the efficacy of two groups were compared.Results After two courses of treatment,the total efficiency of abdominal pain, bloody mucus in experimental group was higher than that in control group （P〈0.05）,but there was no significant difference in total efficiency of diarrhea between two groups （P〉0.05）.After two courses of treatment,the credit value of colonic mucosa in experimental group was less than that in control group（P〈0.05）.The incidence of adverse reactions in control group was higher than that in experimental group （P〈0.05）.Conclusion Mesalazine has good effect in treatment of ulcerative colitis,which is better than sulfasalazine,and it is worthy of clinical application.
出处
《中国当代医药》
2014年第7期57-59,共3页
China Modern Medicine
