摘要
目的观察伊来西胺添加治疗难治性癫痫的疗效与安全性。方法选择本院76例难治性癫痫患者，保持原药不变，添加伊来西胺治疗，随访3～18个月，观察其疗效及不良反应。结果伊来西胺添加治疗难治性癫痫的总有效率为69．7％，对部分性发作和全面性发作均有效，且无明差异，不良反应发生率为23．7％，无严重不良反应。结论伊来西胺治疗难治性癫痫效果较好，安全性高，患者耐受性好，可用于儿童及成人难治性癫痫的添加治疗。
Objective To observe the effect and safety of ilepcimide added in the treatment of intractable epilepsy. Methods 76 patients with intractable epilepsy were selected. The ilepcimide was added on the basis of regular medi- cation.All patients were followed up from 3 to 18 months in order to observe the effect and adverse reaction.Results The total effective rate of ilepcimide added in the treatment of intractable epilepsy was 69.7%. The drug was effective on both partial seizure and generalized seizure,which didn＇t show siguifieant difference.The incidence of adverse reac- tion was 23.7% without serious adverse reaction.Conclusion Ilepcimide has favorable effect in treatment of intractable epilepsy, has advantages of high safety and good tolerance and should be selected as an adjunctive therapy in the treat- ment of intractable epilepsy in both children and adults.
出处
《中国当代医药》
2014年第7期69-71,共3页
China Modern Medicine
