摘要
目的探讨复脉养心汤联合胺碘酮对阵发性心房颤动(PAF)的影响并对其相关机制进行探讨。方法将58例阵发性心房颤动患者按照随机数字表法分为对照组和试验组,每组29例。对照组采用口服胺碘酮治疗,试验组则在对照组的基础上联用复脉养心汤,持续治疗3个月后,随访观察各组患者心电图P波最大持续时间(Pmax)、P波离散度(Pd)、心率以及PAF发作频率,采集静脉血对血清内低氧诱导因子1α(HIF-1α)水平进行比较。结果所有患者治疗后Pmax、Pd、总心率、平均心率、PAF发作总次数、PAF发作平均次数以及血清HIF-1α水平均显著降低(P<0.05),而以试验组降低更为明显(P<0.05)。结论复脉养心汤联合胺碘酮治疗阵发性心房颤动效果肯定,其机制可能为降低了血清内HIF-1α水平。
【Objective】 To explore the effects of combination therapy of Fumaiyangxin decoction and Amiodarone to ECG and related mechanisms in patients with paroxysmal aterial fibrillation（PAF）. 【Methods】 58 patients with PAF were selected and randomly divided into control group and experimental group. Control group received P.O. treatment of Amiodarone, while experimental group received combination treatment of amiodaone and Fumaiyangxin decoction. A 3 month follow up study was used to measure and compare Pmax, Pd, total heart rate（HR）, frequency of PAF and serum level of hypoxia inducible factor- 1 alpha（HIF- 1 al- pha） in two groups. 【Results】 Pmax, Pd, total HR, average HR, total frequency of PAF, average frequency of PAF were decreased significantly in all patients after treatments（P 0.05）; but more significantly in experi- mental group than control group（P 0.05）. 【Conclusion】 Combination therapy of Fumaiyangxin decoction shows positive and confirmed in treatment of PAF, maybe by decreasing level of HIF-1 alpha.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2013年第35期107-110,共4页
China Journal of Modern Medicine
关键词
复脉养心汤
胺碘酮
阵发性心房颤动
低氧诱导因子
Fumaiyangxin decoction
Amiodarone
paroxysmal aterial fibrillation
hypoxia inducible factor
