摘要
目的 观察激素序贯疗法治疗活动期类风湿关节炎的近期临床疗效.方法 活动期类风湿关节炎患者160例,采用数字表法随机分为观察组和对照组,每组各80例.两组患者在给予甲氨蝶呤、来氟米特治疗的基础上,观察组给予激素序贯治疗,对照组给予醋酸泼尼松治疗.对治疗7d及3个月后的临床疗效进行比较分析.结果 观察组治疗7d后各项指标与治疗前相比均有明显下降（t=19.90、7.63、14.73、7.58、6.84、14.09,均P＜0.01）,对照组治疗7d后晨僵时间、关节压痛指数、关节肿胀指数3项指标与治疗前相比明显下降（t=13.42、3.34、7.24,均P＜0.01）,两组治疗7d后各项指标差异均有统计学意义（t=13.07、4.92、10.51、5.23、5.74、15.03,均P＜0.01）.治疗3个月后观察组、对照组各项指标均有明显下降,但两组差异无统计学意（t=1.80、1.73、1.59、1.22、1.21、1.35,均P＞0.05）.观察组总有效率为80%,高于对照组的75%,但差异无统计学意义（x2=0.57,P＞0.05）.结论 激素序贯疗法可有效控制类风湿关节炎患者的症状,改善患者的病情,是治疗活动期类风湿关节炎的一种有效手段.
Objective To observe the recent clinical efficacy of the sequential therapy hormone in the treatment of active rheumatoid arthritis.Methods In accordance with the principle of digital sheet,160 patients with active rheumatoid arthritis were randomly divided into the observation group and the control group,80 cases in each group.On the basis of methotrexate and leflunomide in both groups,the hormone sequential therapy was given in the observation group,but prednisone was given in the control group.The clinical efficacy of treatment after 1 week and 3 months were compared in two groups.Results In the observation group,the indicators in 7 d after treatment were significantly reduced,compared with untreated（t =19.90,7.63,14.73,7.58,6.84,14.09,all P 〈0.01）,In the control group,three indicators of the duration of morning stiffness,joint tenderness index and joint swelling index in 7d after treatment were significantly reduced,compared with untreated （t =13.42,3.34,7.24,all P 〈 0.01）,Compared the indicators in the two groups in 7 d after treatment,there were statistically significant differences （t =13.07,4.92,10.51,5.23,5.74,15.03,all P 〈 0.01）.The indicators in the 3 months after treatment in both groups were signifi cantly decreased,buttherewasnosignificantdifferencebetweenthetwogroups （t =1.80,1.73,1.59,1.22,1.21,1.35,all P 〉 0.05）.The total effective rate was 80% in the observation group; but the rate was 75 % in the control group;there was no statistically significant difference in the two groups（x2 =0.57,P 〉 0.05）.Conclusion The sequential hormone therapy is an effective means for the treatment of active rheumatoid arthritis,by controlled the symptoms of rheumatoid arthritis effectively and alleviated the patient＆#39;s condition.
出处
《中国基层医药》
CAS
2014年第1期51-53,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
关节炎
类风湿
激素类
序贯
Arthritis,rheumatoid
Hormones
Sequential
