摘要
目的：探讨Ia2-Ibl期仅有低分化高危因素宫颈鳞癌患者的治疗模式。方法：采用前瞻性随机对照研究的分析方法，将该院2007年1月-2012年12月收治的Ia2-Ibl期仅有低分化高危因素的宫颈鳞癌患者60例，分为单纯手术组（对照组）和手术＋术后化疗组（观察组），总结所有患者手术并发症和观察组患者的化疗毒副反应。同时对两组间的复发率、3年累积无瘤生存率进行比较。结果：所有患者手术并发症的总发生率为33．33％（20／60），观察绀主要的毒副反应发生率为骨髓抑制16．67％（5／30），胃肠道反应23．33％（7／30），肝肾功能损害3．33％（1／30）；对照组和观察组的复发率分别为6．67％和0．00％，差异无统计学意义（P〉0．05）；3年累积无瘤生存分别为91．83％和100．oo％，差异无统计学意义（P〉0．05）。结论：手术＋术后化疗对于仅有低分化高危因素的Ia2-Ib1期宫颈鳞癌患者是一种可行的治疗选择，患者可耐受手术联合单纯化疗的并发症和毒副反应，并获得较好的近远期疗效。
Objective： To explore the treatment mode of cervical squamous cell carcinoma patients in I a2 - I bl phase with only poorly differentiated high factors. Methods： A Prospective randomized case -control study was performed, 60 cervical squamous cell carci- noma patients in I a2 - I bl phase with only poorly differentiated high factors were selected from the hospital from January 2007 to Decem- ber 2012 were selected and divided into simple surgery group （control group） and surgery ＋ postoperative chemotherapy group （observation group） ; the surgical complications in the two groups and adverse reactions of chemotherapy in observation group were summarized ; the recur- rence rates and three - year cumulative disease - free survival rates in the two groups were compared. Results ： The overall incidence rate of postoperative complications was 33.3% （20/60）, in observation group, the main adverse reactions were myelosuppression （16. 67%, 5/ 30） , gastrointestinal reaction （23.33 % , 7/30） , liver and renal dysfunction （3.33 % , 1/30） ; the recurrence rates in control group and ob- servation group were 6. 67% and 0. 00% , respectively, there was no statistically significant difference （ P 〉 0. 05 ） ; the three - year cumula- tive disease - free survival rates in control group and observation group were 91.83% and 100. 00% , respectively, there was no statistically significant difference （P 〉 0. 05 ） . Conclusion ： Surgery combined with postoperative chemotherapy is a feasible treatment choice for cervi- cal squamous cell carcinoma patients in I a2 - I bl phase with only poorly differentiated high factors, the patients can tolerate the complica- tions and adverse reactions of surgery combined with simple chemotherapy, the short - term and long - term curative effects are good.
出处
《中国妇幼保健》
CAS
北大核心
2014年第7期1009-1011,共3页
Maternal and Child Health Care of China
基金
广西壮族自治区柳州市应用技术研究及技术开发课题〔2010030720〕
关键词
宫颈鳞癌
低分化
术后
化疗
Cervical squamous cell carcinoma
Poor differentiation
Postoperation
Chemotherapy
