摘要
目的明确益母草毒性特点、毒性物质基础和毒性作用机制,探讨药物功效与毒性相关性,为今后安全标准制订和进行功效物质基础下益母草的毒性研究提供文献依据和研究思路。方法对近十几年来益母草相关文献进行整理、归纳与分析。结果常用中药益母草具有活血调经、利尿消肿的功效,是传统的妇科圣药。但关于益母草及含益母草的中成药的不良反应有大量文献报道,现代毒理学实验亦表明益母草有毒性,并初步探讨了其毒性产生剂量、物质基础、作用部位及其产生机制。结论应在益母草功效表达和功效物质基础分离与控制的过程中,正确认识药物功效、毒性和不良反应之间的关系,提出切合益母草临床使用过程中药品不良反应的预警方案和早期诊疗措施,制定益母草毒性物质基础的安全限度和药效物质基础的含量标准,为临床使用益母草提供安全保障。
Objective The toxicity characteristics, chemical material basis and toxic mechanism of Herba Leonuri were determined and the correlation of its efficacy and toxicity were discussed. The literature evidence and research ideas were provided for making safety standards, and studying its toxicity based on its efficacious substance basis. Methods Literatures in latest decades at home and abroad about Herba Leonuri were collated, analyzed and summarized. Results As a commonly used traditional Chinese medicine, Herba Leonuri, which has the efficacy of promoting blood flow for regulating menstruation, diuresis and edema was a traditional Chinese medicine. A number of adverse reactions of Herba Leonuri or Chinese patent drugs containing it were reported. Modern toxicology studies have shown that Herba Leonuri had toxicity, and the dose range, substance basis, site of action and damage mechanism were discussed by toxicology experiment. Conclusion The Herba Leonuri toxicity and controlling of toxic material basis are studied during the expression of effectiveness and the separation and quality controlling of efficacious material basis, the relationship between the drug efficacy, toxicity and adverse reactions are determined. And we can put forward early-warning scheme and treatment measures of adverse reaction in clinical usage. The safety limitation and standard of content of material basis from Herba Leonuri are established to ensure the safe use of Herba Leonuri as a clinical drug.
出处
《中国药物警戒》
2014年第2期70-73,共4页
Chinese Journal of Pharmacovigilance
基金
国家中医药管理局中医药科学技术研究专项"有毒中药"质量控制及有毒成分限量示范研究(2004ZX00)
关键词
益母草
毒性特点
物质基础
毒性机制
Herba Leonuri
toxicity characteristics
chemical material basis
toxicity mechanism
