摘要
[目的]旨在优化乙嘧酚的合成工艺,寻找一条适合工业生产的工艺路线。[方法]以硫脲为原料,经过甲基化、乙胺取代、环合得到目标产物乙嘧酚。[结果]目标产物的总收率达70.5%,其结构经MS、1H N M R确证。[结论]该路线原料易得、收率较高、操作简便、条件温和,为工业化生产奠定了基础。
[Aims] This study aims to obtain a reasonable synthetic route of ethirimol on industrial scale. [Methods] Ethirimol was synthesized from thiourea via four steps including alkylation, methylation, ethylamine substitution and cyclization. [Results] The total yield was 70.5%. The structures of products and intermediates were determined by 1H NMR or MS. [Conclusions] The synthesis technology has advantages of easily available raw materials, high yield, simple operation and mild conditions, which lays the groundwork for industrial production of ethirimol.
出处
《农药》
CAS
CSCD
北大核心
2014年第3期174-175,共2页
Agrochemicals
关键词
杀菌剂
乙嘧酚
合成
fungicides
ethirimol
synthesis
