摘要
质子泵抑制剂(PPI)已成为消化性溃疡的重要药物,既有利于溃疡创面的愈合,又可以为抗生素根除幽门螺杆菌提供适合的酸性环境。随着对CYP2C19基因多态性研究的不断深入,近期一些研究表明CYP2C19基因多态性对消化性溃疡质子泵抑制剂及幽门螺杆菌治疗的疗效有着重要的影响,本文就CYP2C19基因多态性指导消化溃疡质子泵抑制剂及抗Hp治疗的价值做简要综述。
Proton pump inhibitors （PPI） has become the important drugs to treat peptic ulcer, which can pro- mote the healing of ulcer wound, and can offer acidic environments for antibiotics eradicate Helicobacter pylori （HP）. Along with the deepening research of the CYP2C19 genetic polymorphism, some studies have recently shown that CYP2CI 9 gene polymorphisms have the important influence for the curative effect of proton pump inhibitors in the treatment of peptic ulcer and HP therapy. In this paper, the value of CYP2C19 genetic polymorphism to guide proton pump inhibitors in the treatmentof digestive ulcer and HP is reviewed.
出处
《海南医学》
CAS
2014年第3期372-375,共4页
Hainan Medical Journal
