摘要
MicroRNA(miRNA)是一类内源性非编码小分子RNA,在肿瘤的发生和发展中起着至关重要的作用。近年来人们在血清/血浆、脑脊液、唾液、尿液及乳汁等体液中发现了稳定存在的循环miRNA,在不同的恶性血液病中循环miRNA具有不同的表达谱,并且与患者的疾病状态、预后等相关,这为恶性血液病的诊断、预后评估及靶向治疗提供了新的思路。本文就循环miRNA、循环miRNA的存在形式及功能、循环miRNA与恶性血液病进行综述。
MicroRNAs（miRNAs） are a class of endogenous small non-coding RNAs that play an important role in the pathogenesis and progression of tumor.Recently,it is discovered that circulating microRNA exist stably in body fluids,such as serum/plasma,cerebrospinal fluid,saliva,urine,breast milk and so on.Circulating microRNA profiles now have been associated with different hematologic malignancy types,disease states and prognosis.They may serve as a new class of non-invasive diagnostic or prognostic biomarkers,and even the potential therapeutic targets in hematologic malignancies.In this article,the circulating miRNA,existent pattern and function of circulating miRNA,and circulating miRNA and hematologic malignancies are reviewed.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2014年第1期219-222,共4页
Journal of Experimental Hematology
