摘要
采用反相高效液相色谱法测定犬口服芎芍胶囊后阿魏酸的血药浓度 ,以 3P87药代动力学软件拟合药动学模型。结果表明犬灌胃芎芍胶囊后阿魏酸的体内过程符合开放性一室模型 ,测得药代参数为Ⅰ级吸收速度常数 =0 0 74 9± 0 0 2 0 2 (min- 1) ,Ⅰ级消除速度常数 =0 0 159± 0 0 0 2 0(min- 1) ,半吸收期 =9 73± 2 38(min) ,半衰期 =4 4 2 5± 5 52 (min) ,达峰时间 =2 9 39± 4 10(min) ,血药峰浓度 =150 9 52± 2 75 81(μg/L)。为临床合理用药提供了实验依据。
The blood concentration of ferulic acid (FA) was determined by RP HPLC after the dog was intragastrically given Xiongshao Capsules (XC) which contains FA, and 3P87 Pharmacokinetics Program was used to fit the pharmacokinetic model. The results showed that the concentration time curves of FA after giving a single dose of XC to the dog intragastrically were fit to the one compartment open model, and the pharmacokinetic parameters found in the experiment were ka=0 0749±0 0202 (min -1 ), ke=0 0159±0 0020 (min -1 ), t 1/2Ka =9 7346±2 3774 (min), t 1/2Ke =44 2539±5 5179 (min), t peak =29 3386±4 1009 (min), c max =1509 5180±275 8128 (μg/L).
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2001年第1期25-28,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
"九五"国家科技攻关课题 !(No .96_90 6_0 6_0 1)
