摘要
目的探讨磁共振T2 mapping成像对基质诱导的自体软骨细胞移植(MACI/MACT)术后的评估价值。方法 4例接受MACI治疗的膝关节软骨损伤患者(10处软骨损伤),分别在术后1、3、6个月进行磁共振T2 mapping检查,测量各时间点移植区与正常区软骨全层的T2值,并进行统计学分析。各个时间点移植区与正常区T2值比较采用配对t检验,移植区T2值的纵向对比采用单因素方差分析。结果 MACI术后1、3、6个月移植区的T2平均值分别为(82.40±15.23)、(71.09±13.06)、(53.80±4.86)ms。术后6个月内移植区T2值均大于正常区,1、3个月组差异均有统计学意义(P均<0.01),6个月组差异无统计学意义(P=0.196)。术后1、3、6个月移植区T2值纵向变化差异有统计学意义(P=0.03)。结论磁共振T2 mapping成像能够无创、动态地监测移植软骨的修复过程,可作为软骨修复术后评估的有力工具。
Objective To evaluate the value of T2 mapping in monitoring the repaired cartilage after matrix-associated autologous chondrocyte implantation/transplantation （MACI/MACT）. Methods Four pa- tients （ 10 plug cartilages） were examined three times by T2 mapping at 1, 3, and 6 months using a 3.0 Tesla MR scan system. Quantitative mean （full-thickness） T2 values were calculated in the transplanted area and con- trol cartilage. Paired t-tests were used to compare the T2 values between transplanted and control cartilage. For analysis of longitudinal T2 values, one-way analyses of variance were performed among 1, 3, and 6 months after MACI. Results The mean T2 values of the transplanted area at 1, 3, and 6 months after MACI were （82. 40 ±15.23）, （71.09 ±13.06）, （53.80 ±4. 86） ms, respectively. There were significant differences between the transplanted and control cartilage at 1 and 3 months （ both P 〈 0. 01 ） after MACI, but not at 6 months （ P = 0. 196）. There were significant differences among T2 values of 1, 3, and 6 months after MACI in transplanted area （P = 0. 03 ）. Conclusion T2 mapping provides a useful tool for monitoring the biochemical development of the transplanted cartilage and can be used to evaluate the cartilage repair noninvasively.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2014年第1期86-91,共6页
Acta Academiae Medicinae Sinicae
关键词
T2值
软骨
膝关节
基质诱导的自体软骨细胞移植
T2 value
cartilage
knee
matrix-induced autologous chondrocyte implantation/transplantation
