摘要
目的:系统评价百令胶囊治疗稳定期慢性阻塞性肺疾病(COPD)的疗效。方法:计算机检索Cochrane Library、PubMed、EMbase、中国期刊全文数据库、中国生物医学文献数据库、万方数据库和维普数据库,收集百令胶囊治疗稳定期COPD的随机对照试验(RCT),对入选文献进行质量评价,采用Rev Man 5.2统计软件对提取数据进行Meta分析。结果:最终纳入6项RCT,共588例患者。Meta分析结果显示,百令胶囊能改善稳定期COPD患者第一秒用力呼气容积[MD=0.14,95%CI(0.04,0.25),P=0.006]、动脉血氧分压[MD=3.59,95%CI(1.50,5.68),P=0.001]、动脉二氧化碳分压[MD=-2.38,95%CI(-4.12,-0.63),P=0.008]和6 min步行距离[MD=49.59,95%CI(32.29,66.89),P<0.000],差异均具有统计学意义。结论:百令胶囊可以改善稳定期COPD患者的动脉血气指标、肺功能指标和运动耐量水平。因本文纳入研究较少,质量不高,此结论还需要更多大规模、高质量的RCT证实。
OBJECTIVE： To evaluate the therapeutic efficacy of Bailing capsule for stable chronic obstructive pulmonary disease （COPD）. METHODS： Retrieved from Cochrane Library, PubMed, EMbase, CNKI, CBM, Wanfang database and VIP database, RCTs about Bailing capsule in the treatment of stable COPD were included; the quality of selected literatures was evaluated and Meta-analysis was conducted using Rev Man 5.2 software. RESULTS： A total of 6 studies were included, involving 588 patients. Meta-analysis demonstrated that Bailing capsule could improve FEVI [MD=0.14, 95%CI （0.04,0.25）, P=0.006], Pbt（O2） [MD=3.59, 95%Cr （1.50,5.68）, P=0.001], Pbt（C02） [MD= -2.38, 95%Cr（ -4.12, -0.63）, P=0.008] and 6-min walking distance [MD=49.59, 95% CI （32.29, 66.89）, P〈0.000] in patients with stable COPD; there were statistically differences. CONCLUSIONS： Bailing capsule could improve arterial blood gas index, pulmonary function index and exercise tolerance in patients with stable COPD; but more large-scale and high-quality RCTs are required due to few and low quality included studies.
出处
《中国药房》
CAS
CSCD
2014年第12期1115-1117,共3页
China Pharmacy
