摘要
目的 报道 1例同时具有t(8;2 1)和t(15 ;17)的染色体复杂异常的急性髓系白血病(AML)。方法 骨髓细胞经过 2 4h培养 ,按常规方法制备染色体标本 ,用R显带技术进行核型分析。以RT PCR方法检测AML1/ETO、PML RARα融合基因。结果 染色体核型分析结果为 45 ,X ,-X ,t(8;2 1) ,t(15 ;17)。RT PCR方法检测发现AML1/ETO及PML RARα融合基因转录本。结论 同时具有t(8;2 1)和t(15 ;17)的AML有可能为一新的临床遗传学类型。
Objective To report an acute myeloid leukemia (AML) patient with both chromosome t(8;21) and t(15;17). Methods Chromosome specimen was prepared by short term culture of bone marrow cells, karyotype analyses by R banding technique, and fusion genes by reverse transcriptase polymerase chain reaction (RT PCR). Result Karyotype analyses showed the appearance of 45, X, -X,t(8;21),t(15;17), and RT PCR assay revealed AML1/ETO and PML RARα fusion gene transcripts. Conclusion AML with both t(8;21) and t(15;17) might be recognized as a a novel subtype of acute leukemias.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2001年第2期94-95,共2页
Chinese Journal of Hematology
