摘要
目的探讨多奈哌齐联合康复训练治疗老年痴呆患者的临床效果。方法选取2010年6月至2013年6月我院收治的老年痴呆患者144例，随机将其平均分为实验组及对照组，均口服多奈哌齐，实验组再行康复训练，均治疗8周，并观察两组治疗效果。结果治疗后实验组显效63例，有效7例，无效2例，总有效率97．2％；对照组显效42例，有效24例，无效6例，总有效率91．7％。实验组总有效率高于对照组，而且实验组MMES评分、BEHAVE—AD评分改善情况优于对照组，差异均具有统计学意义（P〈0．05）。结论多奈哌齐联合康复训练治疗老年痴呆临床效果显著，可有效改善患者精神状态及认知功能，并建议在临床治疗中推广应用。
Objective To study the clinical efficacy of donepezil and rehabilitation training for patients with Alzheimer＇ s disease. Methods 144 patients with Alzheimer＇ s disease were chosen from our hospital from June, 2010 to June, 2013 and then were randomly and averagely divided into a treatment group and a control group. The control group were treated with donepezil for 8 weeks. And the treatment group were given donepezil and rehabilitation training for 8 weeks. The clinical efficacies were observed. Results 63 patients responded to the treatment well, 7 just responded to, and 2 did not in the treatment group, with a efficacy of 97.2%. 42 patients responded the treatment well, 24 just responded to, and 6 did not in the control group, with a efficacy of 91.7%. The values of MMES and BEHAVE-AD were improved more in the treatment group than in the control group. Conclusions Donepezil and rehabilitation training for patients with Alzheimer＇ s disease is effective, can improve the patients＇ mental status and cognitive function, and is worth being clinically generalized.
出处
《国际医药卫生导报》
2014年第6期835-837,共3页
International Medicine and Health Guidance News
关键词
老年痴呆
多奈哌齐
康复训练
临床效果
Alzheimer＇ s disease
Donepezil
Rehabilitation
Clinical efficacy
