摘要
目的评价血清CEA、CYFRA21-1和NSE对非小细胞肺癌(NSCLC)临床诊断的价值。方法采用电化学发光法检测75例NSCLC患者,健康对照组35例血清中CEA、CYFRA21-1和NSE的浓度。结果 NSCLC患者血清CEA、CYFRA21-1和NSE水平显著高于对照组,差异有统计学意义(P<0.05)。CEA、CYFRA21-1和NSE的敏感性分别为61.5%、66.2%和33.8%。CEA在腺癌的敏感性64.3%,CYFRA21-1在鳞癌的敏感性89.6%,显著高于腺癌,差异有统计学意义(P<0.05),NSE在非小细胞肺癌中的敏感性33.8%。结论 CEA及CYFRA21-1是较好的诊断非小细胞肺癌的肿瘤标志物(TM),CYFRA21-1对NSCLC的诊断特别是鳞癌有重要的意义,CEA较适用于腺癌,NSE在腺癌和鳞癌中的敏感性没差别,但对NSCLC的诊断也有一定价值。
Objective To evaluating the diagnostic values of the CEA、CYFRA21-1and NSE in serum of non-small cell lung cancer patiens （NSCLC）.Methods A NSCLC study group had 75 cases,and a healthy control group had 35 case.Were measured by electrochemilumin escence immunoassays.Results In the NSCLC groups the serum CEA,CYFRA21-1,NSE using levels were hinger than those in the healthy control groups （P〈0.05）.The sensitivities of CEA、CYFRA21-1 and NSE to determine non-small cell lung cancer serum were 61.5%、66.2% and 33.8%.The sensitivitie of CEA in adenocarcinoma was 64.3% .The sensitivitie of CYFRA21-1 was higher in squamous cell carcinoma than adenocarcinoma.（P〈0.05）.The sensitivitie of NSE was 33.8% in serum of non-small cell lung cancer patiens.Conclusion CEA and CYFRA21-1 was a good diagnosis of non-small cell lung cancer tumor markers （TM）,CYFRA 21-1 was of the most value for the diagnosis of NSCLC,especially squamous cell carcinoma.CEA was suitable for the adenocarcinoma.NSE in adenocarcinoma and squamous carcinoma of the sensitivity no difference,but for the diagnosis of NSCLC also have certain value.
出处
《河南外科学杂志》
2014年第1期4-6,共3页
Henan Journal of Surgery
