摘要
目的探讨高初始浓度七氟烷吸入诱导全身麻醉的安全性和有效性。方法选取择期手术全麻的成年患者300例,ASAⅠ～Ⅱ级,按手术日期单双号半随机分为两组,均予七氟烷麻醉诱导。低初始浓度组179例,最初给予低的初始浓度(0.5%),然后逐渐增加剂量,直到病人被麻醉。高初始浓度组121例,开始即给予高浓度(4%～8%),直到病人被麻醉。两种方法均可使用不同呼吸模式,记录睫毛反射消失时间和不良反应发生例数。结果高初始浓度组睫毛反射消失时间明显短于低初始浓度组,差异有统计学意义(P<0.01)。两组的各种不良反应的发生率差异均无统计学意义(P>0.05)。结论高初始七氟烷浓度与低初始浓度相比诱导时间更短,并发症发生率差异均无统计学意义,值得推广应用。
Objective To investgatd the safety and efficacy of the high initial concentration sevoflurane for inhalational induction of general anaesthesia .Methods Three hundred adult patients undergoing elective surgery an-esthesia , ASAⅠ~Ⅱ, were randomly divided into two groups according to odd or even number of operative date .The low initial concentration group （179 cases） was initially administered a low concentration of sevoflurane then the con-centration was gradually increased until the patient was anaesthetized .The high initial concentration group （ 121 ca-ses） was administered high concentrations of sevoflurane （ from 4%to 8%） from the beginning , continuing until the patients was anaesthetized .Both techniques can be carried out using different breathing patterns .Time to loss of eye-lash reflex（LOER）（seconds）, complication rates in the two groups were recorded .Results Time to LOER in high initial concentration group was obviously shorter than the lower initial concentration groups , the differences were statis-tically significant （P＆lt;0.01）.There was no difference in the incidence of adverse effects between the two groups （P＆gt;0.05 ） .Conclusion Compared with low initial concentration of sevoflurane a high initial concentration sevoflurane probably offers more rapid induction of anaesthesia and a similar rate of complications , especially worth promoting .
出处
《中国临床新医学》
2014年第2期144-146,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词
七氟烷
麻醉诱导
不良反应
Sevoflurane
Anesthetic induction
Adverse effects
