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浆母细胞淋巴瘤的病理、分子生物学及临床特征 被引量：8

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摘要 浆母细胞性淋巴瘤(PBL)是具有浆母细胞形态和免疫表型特征的弥漫性大B细胞淋巴瘤。1997年Delecluse等报道了一系列发生于艾滋病患者的原发于口腔的侵袭性非霍奇金淋巴瘤,肿瘤由具有浆细胞分化的大细胞组成,这类肿瘤首次被称为浆母细胞淋巴瘤。由于PBL高度侵袭的本质和浆细胞分化的特点,WHO(2008)淋巴及造血系统肿瘤分类将其划归为弥漫性大B细胞淋巴瘤(DLBCL)的一种罕见亚型。目前认为,HIV、EBV感染及Myc基因异位可能与PBL发病有关。由于其形态学具有浆母细胞分化的特点,与其他具有类似特点的淋巴造血系统肿瘤鉴别困难;另外,虽然PBL的早期治疗效果明显,但复发率高且预后极差。鉴于此,本文主要对PBL的病因、临床表现、病理学特点、分子遗传学改变等几个方面进行阐述,希望加深对本病的认识和了解。
作者 范国庆 刘一雄 张月华 王映梅 王哲 闫庆国 郭英
机构地区 第四军医大学肿瘤生物学国家重点实验室病理学与病理生理学教研室西京医院病理科 第四军医大学
出处 《诊断病理学杂志》 CSCD 北大核心 2014年第2期117-120,共4页 Chinese Journal of Diagnostic Pathology
基金 国家自然科学基金项目(No.81071951) 陕西省自然科学基金项目(No.2009JM4002-2)
关键词 浆母细胞淋巴瘤 HIV EBV MYC易位 间变性浆细胞瘤
分类号 R733 [医药卫生—肿瘤]
  • 相关文献

参考文献22

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二级参考文献24

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共引文献6

同被引文献65

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引证文献8

二级引证文献13

诊断病理学杂志
2014年 第2期

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