摘要
目的探讨亚甲基四氢叶酸还原酶（MTHFR）基因1298位点多态性及叶酸水平等因素与宫颈癌易感性的关系。方法于2007年至2011年，收集在厦门市妇幼保健院、厦门市第一医院和厦门市中医院就诊的129例宫颈癌患者作为病例组，并以同期健康体检的妇女214例作为对照组，检测其血清中叶酸、维生素B1z水平及MTHFR1298基因表达情况，同时对其进行问卷调查。结果①宫颈癌组的叶酸水平为（13．29±8．47）nmol／L低于对照组的（16．75±7．92）nmol／L（P=0．001），并且其人乳头瘤状病毒（HPV）阳性率及首次生育年龄在25岁以下的比例分别为73．6％和68．22％，高于对照组的25．7％（X2=75．178，P=0．001）和54．20％（X2=6．556，P=0．001）。②两组中MTHFRl298位点的分布差异有统计学意义（X2=12．466，P=0．002），与携带AA基因型者相比，携带AC（OR=1．831，95％CI为1．309～2．562）及CC基因型（OR=5．804，95％CI为2．187～15．405）者患宫颈癌的风险更高（P〈0．05）。③将AA和AC基因型合并为一组，分析发现宫颈癌组与对照组在基因型构成比方面的差异也有统计学意义（X2=4．527，P=0．033），OR=4．650（95％CI为1．129～19．150）。结论宫颈癌的发病可能与体内叶酸水平偏低及生育年龄过早有关，在MTHFR1298基因多态性中，携带AC或CC基因型可能是宫颈癌发病的易感基因，尤其是CC基因型。
Objective To study the relationship between the occurrence of the uterine cervix cancer and the risk factors, such as the methylene tetrahydrofolate reductase （MTHFR） 1298 polymorphism, the level of the folic acid and so on. Methods The cases from some hospitals, including the Xiamen No. 1 Hospital, the Xiamen Maternal and Child Health Hospital and the Xiamen Traditional Chinese Medical Hospital during the year 2007 to 2011 were selected and divided into two groups, one was the cancer group with 129 cases of the cervical cancer, and the other was the control group with 214 non-cervical-cancer women. Through using the questionnaires and testing the expression of the MTHFR 1298 polymorphism, the the risk factors of cervical cancer were analyzed. Results （1） The level of the folic acid in the cancer group was （13.29±8.47） nmol/L, lower than that of the control group [（16. 75±7. 92） nmol/L3 （P=0. 001）. The ratio of the positive result of the human papillomavirus （HPV） in the cancer group was 73.6%, higher than that of the control, group （25.7%） （X2±75. 178, P=0. 001）. What＇s more, the ratio of the first parturition age below 25 years old in the cancer group was 68.22%, also higher than the ratio of the control group （54. 2%） （X2=6. 556, P= 0. 001）. （2） The difference of the distribution of MTHFR 1298 polymorphism between the two groups was significant （X2 = 12. 466, P= 0. 002）, contrast with the women whom had the MTHFR 1298AA, the women whom carried the MTHFR 1298AC had much more risk to get the cervical cancer （OR=1. 831,95% CI： 1. 309-2. 562）, so did the women whom carried the MTHFR 1298CC （OR=5. 804, 95% CI： 2. 187-15. 405）. （3） After combining the two gene types which were the MTHFR 1298AA and the MTHFR 1298AC into one group, the difference of the distribution of the MTHFR 1298 polymorphism between the cancer group and the control group was also significant （Z2 = 4. 527, P = 0. 033）, OR = 4. 650 （95% CI： 1. 129- 19. 150）. Conclusion The occurrence of the cervical cancer may associate with the low level of the folic acid and the first parturition age below 25 years old. Meanwhile, the MTHFR 1298 polymorphism may be an important factor to the occurrence of cervical cancer, the MTHFR 1298AC or MTHFR 1298CC may increase the risk to get the cervical cancer, especially the MTHFR 1298CC genotype.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2014年第2期258-261,共4页
Journal of Sichuan University(Medical Sciences)
基金
厦门市重大疾病科研攻关项目(No.XMWZK0602)资助
关键词
MTHFR基因
多态性
叶酸
宫颈癌
The Methylene tetrahydrofolate reductase （MTHFR） Polymorphism Folic acid Cervical cancer
