摘要
目的探讨青少年期与成年期发病精神分裂症患者健康一级亲属认知功能损害的差异。方法选取年龄、性别、文化程度等匹配的青少年期发病精神分裂症患者一级亲属49例、成年期发病患者一级亲属50例及健康对照50例,利用Stroop测验、威斯康辛卡片分类测验(WCST)、字母划消测验及数字倒背测验,测评上述健康被试的注意、记忆及执行功能。结果威斯康辛卡片分类测验结果中,完成分类数及持续错误数三组间差异有统计学意义(均P<0.05),其中完成分类数两亲属组差异有统计学意义(P<0.05)。Stroop测验中色-词项目三组间差异有统计学意义(P<0.01),两亲属组间差异有统计学意义(P<0.01)。字母划消及数字倒背测验中,三组遗漏数及倒背数差异均有统计学意义(P分别<0.01和<0.05),遗漏数项目两亲属组差异有统计学意义(P<0.05)。结论精神分裂症患者健康一级亲属注意稳定性、注意灵活性及注意分配功能下降,工作记忆及执行功能均受损。且在额叶执行功能、注意分配功能及注意稳定性方面,青少年期发病精神分裂症患者一级亲属较成年期发病者一级亲属受损更严重。
Objective To explore the cognitive function in unaffected first degree relatives of schizophrenia attacked in the adolescent and adult periods.Methods The study involved 49 unaffected first degree relatives of schizophrenia attacked in the adolescent period,50 in the adult period and 50 healthy controls.They were matched in the age,sex and education.Wisconsin card sorting test（WSCT）,Stroop color-word test,letter deleting test,number reciting backward test were used to assess the attention,memory and executive functions.Results There was significantly worse performance in category completed and perseverative errors of WSCT in two relative groups than in control group.The relatives of schizophrenia attacked in the adolescent period had worse scores in category completed than those in the adult period （P ＜ 0.05）.The subjects showed significantly worse performance in color-word item of Stroop test in two relative groups than in control group（P ＜0.05）.The relatives of schizophrenia attacked in the adolescent period had less scores in color-word item than that in the adult period（P ＜0.01）.The numbers ignored item and numbers recited backward item were not significantly different among three groups （F =5.67,P ＜ 0.01;F =3.37,P ＜ 0.05）.The relatives of schizophrenia attacked in the adolescent period had more numbers ignored than those in the adult period（P ＜ 0.05）.Conclusion In addition to the decrease of attentive allocation,stability and exibility,the first degree relatives have memory and executive function deficits.The relatives of schizophrenia attacked in the adolescent period have more serious deficits in excutive function,attentive allocation and stability than those in the adult period.
出处
《山西医科大学学报》
CAS
2014年第2期106-108,共3页
Journal of Shanxi Medical University
基金
兰州军区科技基金资助项目(CLZ12JB23)
关键词
精神分裂症
认知功能
对照研究
schizophrenia
cognitive function
control trial
