摘要
目的探讨重型颅脑伤患者血清及脑脊液中水通道蛋白质4(aquaporin-4,AQP-4)的表达水平及其意义。方法选取我科重型颅脑损伤46例手术患者,分别在手术时、手术后3 d、手术后1周采集血清及脑脊液,应用酶联免疫吸附法检测血清及脑脊液中AQP-4水平。结果在手术时、手术后3 d及手术后1周重型颅脑损伤患者血清及脑脊液均可检测到AQP-4,术后3 d较手术时升高(P<0.05),术后1周AQP-4水平较术后3 d降低,差异具有统计学意义(P<0.05)。结论重型颅脑损伤后患者血清及脑脊液中AQP-4水平随着病程进展变化,推测AQP-4可能参与了脑损伤过程。
Objective To explore the levels of water channel protein 4 （aquaporin-4,AQP-4） in the serum and cerebrospinal fluid of patients with severe traumatic brain injury and its clinical significance.Methods In 46 patients with severe traumatic brain injury,the levels of AQP-4 in the serum and and cerebrospinal fluid were measured by enzyme linked immunosorbent assay during the opreration,3 d and 1 week after operation.Results AQP-4 existed in the serum and cerebrospinal fluid of patients with severe traumatic brain injury at different time.The levels of AQP-4 increased 3 d after operation（P ＜0.05）,and then statistically decreased 1 week after operation（P ＜ 0.05）.Conclusion The level of AQP-4 in patients with severe traumatic brain injury changes with the progression of the disease,suggesting that AQP-4 may be involved in the process of brain damage.
出处
《山西医科大学学报》
CAS
2014年第2期134-136,共3页
Journal of Shanxi Medical University
基金
陕西省科学技术研究发展计划基金资助项目(2012SF2-02-05)
关键词
重型颅脑损伤
水通道蛋白-4
血清
脑脊液
severe traumatic brain injury
aquaporin-4
serum
cerebrospinal fluid
