摘要
目的探讨舒必利辅助治疗反流性胃炎的临床疗效。方法将焦作市第五人民医院诊治的164例反流性胃炎患者随机分成两组:实验组82例,采用舒必利联合用药方案治疗;对照组82例,采用吗丁啉联合用药方案治疗。观察两组反流性胃炎患者的胃镜检查结果、症状积分、症状改善情况及复发情况。结果实验组近期总有效率明显高于对照组(P<0.05);实验组治疗后的腹胀、上腹痛、烧心感、恶心呕吐等症状积分均明显低于对照组(P<0.05);实验组胆汁反流、胃黏膜损伤和腹痛的消失时间均明显短于对照组(P<0.05);实验组疾病复发率明显低于对照组(P<0.05)。结论舒必利能抑制呕吐中枢进而减少胆汁反流,促进症状缓解及胃损伤黏膜的修复。
Objective To investigate the clinical value of sulpiride in treatment of reflux gastritis. Methods The 164 cases of reflux gastritis patients were randomly divided into two groups： control group （n = 82） and treatment group （n = 82）. The treatment group was treated with sulpiride combination regimen, and the control group was treated with domperidone combination regimen. The clinical effect, symptom scores, recovery time, and the recurrence rate in two groups were observed and compared. Results The total effective rate in the treatment group was significantly higher than that in the control group （P 〈 0.05） ; the symptom scores of abdominal distension, abdominal pain, heartburn, nausea, and vomiting in the treatment group were significantly lower than＇ those in the control group （ P 〈 0.05 ） ; the disappearance time of bile reflux, gastric ulcer and abdominal pain in the treatment group were significantly shorter than those in the control group （P 〈 0.05） ; the recurrence rate in the treatment group was significantly lower than that in the control group （P 〈 0.05）. Conclusion Sulpiride can inhibit the vomiting center and also reduce bile reflux to promote relieve symptom and repair of injured gastric mueosa.
出处
《胃肠病学和肝病学杂志》
CAS
2014年第3期283-285,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
反流性胃炎
舒必利
Reflux gastritis
Sulpiride
