摘要
Objective： Many investigations have studied the associations between matrix metalloproteinase-9 （MMP-9） C1562T polymorphisms and coronary artery disease （CAD）. However, the conclusions of these studies were incon- sistent. Therefore, this study was aimed at clarifying the association between MMP-9 C1562T polymorphisms and CAD in a large-scale meta-analysis. Methods： The PubMed and Embase databases were retrieved to collect all pub- lications on the association between MMP-9 C1562T polymorphisms and CAD. Then the odd ratios （ORs） and 95% confidence intervals （95% CIs） for C1562T TT＋TC versus CC genotype between CAD and the control groups were evaluated. Subgroup analysis was also performed according to different races. The meta-analysis was performed by Stata 10.0. Results： Sixteen case-control studies were included in our meta-analysis, involving 11032 CAD patients and 4628 non-CAD controls. Compared with C allele carriers, East Asian T allele carriers TT＋TC had a significantly higher risk of CAD （OR=1.43; 95% CI： 1.03-1.99; P=0.031）; however, there were no significant associations in Western populations （OR=1.06; 95% CI： 0.96-1.18; p=0.240） or West Asians （OR=1.13; 95% CI： 0.75-1.70; P=-0.565）. When further analyzing the association between C1562T polymorphisms and myocardial infarction （MI, the most serious type of CAD）, the risk of TT＋TC genotype versus CC genotype for MI was significantly higher for the overall （OR=1.21; 95% C1： 1.04-1.40; P=0.012） and for East Asians （OR=1.58; 95% C1： 1.26-1.97; P=0.000） but not in Western populations （OR=1.12; 95% CI： 0.99-1.26; P=0.078）. Conclusions： Our meta-analysis suggested an obvious ethnic difference in the association between MMP-9 C1562T polymorphisms and CAD. MMP-9 C1562T polymorphism was significantly related to CAD in East Asians. However, no significant associations were observed in either West Asians or Western populations.
