摘要
以不同分子量的壳聚糖为原料制备了一系列羧甲基壳聚糖 ,测定了取代度 ( DS)和分子量 ( Mη) ,并用FT-IR及 1 3C NMR进行了分子结构表征 .结果表明 ,在 2位氨基及 3、6位羟基上均发生了羧甲基化反应 ,产物为 N ,O-羧甲基壳聚糖 ( NOCC) .取代度大小顺序为 :OH-6>OH-3>— NH2 ,且总取代度随壳聚糖分子量的降低明显增大 . N ,O-羧甲基壳聚糖具有与透明质酸相似的吸湿、保湿效果 ,其吸湿性能随分子量的增大而增强 ,保湿性能随取代度的增高而增强 ,分子量介于 0 .56× 1 0 4～ 8.6× 1 0 4,取代度大于 1 .0的产品 ,其保湿性能优于透明质酸 .
A series of N,O carboxymethylchitosan(CM chitosan) were prepared. The position and degree of substitution were determined by potentiometric titration, IR and 13 C NMR . The results indicated that the degree of substitution of the compounds increased significantly with decrease of molecular weight of chitosan and the carboxymethylation reactivity decreased in the order OH 6>OH 3>NH 2. The moisture absorption and moisture retention properties of CM chitosans and moisture retention properties of CM chitosans were found quite similar to those of hyaluronic acid. The moisture absorbability increased with increasing in molecular weight and moisture retention capacity of CM chitosas with the degree of substitution. The CM chitosans with molecular weight from 0 56×10 4 to 8 6×10 4 and degree of substitution greater than 1 0 had better moisture absorption moisture retention capacity than hyaluronic acid.
出处
《应用化学》
CAS
CSCD
北大核心
2001年第1期5-8,共4页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金!资助课题 (2 99770 14 )
中金集团资助
关键词
羧甲基壳聚糖
吸湿性
保湿性
取代度
分子量
carboxymethylchitosan,moisture absorption,moisture retention,substitution degree,molecular weight
