摘要
目的系统评价小剂量丙种球蛋白(IVGG)联合糖皮质激素治疗儿童特发性血小板减少性紫癜(ITP)的临床疗效。方法检索2000—2013年中国期刊网、万方数据库及中国生物医学文献数据库,获得国内已发表的小剂量IVGG联合糖皮质激素治疗儿童ITP的相关文献。比较小剂量、大剂量IVGG联合糖皮质激素治疗儿童ITP的总有效率,并用Cochrane Rev Man5.0统计软件进行Meta分析。结果共检索到符合条件的文献5篇,小剂量组总有效率与大剂量组比较差异无统计学意义(Z=0.72,P>0.05)。结论小剂量IVGG联合糖皮质激素可以取得与标准剂量IVGG联合糖皮质激素治疗基本相同的疗效,对于儿童ITP建议采用小剂量IVGG联合糖皮质激素治疗。
Objective To evaluate the clinical effects of low dose gamma globulin（IVGG） combined with glucocortieoids on idiopathic thrombocytopenic purpura（ITP） in children. Methods The literature about the treatment of ITP with IVGG and glucocorticoids （2000-2013） was searched using China National Knowledge Infrastructure,Wanfang Data Konwledge Service Platform and China Biological Medicine Database. The total effective rates of low and high dose IVGG combined with glucocorticoids for ITP were compared and meta-analysis was performed using sta- tistical software Cochrane Rev Man5.0. Results Five articles were eligible for review. There were no significant differences in the total effective rates between low dose and high dose IVGG（Z= 0. 72,P〉0. 05）. Conclusion Low dose IVGG combined with glucocorticoids has the same efficacy as standard dose IVGG combined with glucocorticoids. Therefore, low dose IVGG combined with glucocorticoids was recommended for children with ITP.
出处
《南昌大学学报（医学版）》
CAS
2013年第11期39-41,45,共4页
Journal of Nanchang University：Medical Sciences
