摘要
前列腺素D2（prostaglandinD2，PGD2）是由支气管哮喘（简称哮喘）患者的肥大细胞等分泌的一种主要的前列腺素类物质。尽管它在哮喘发病机制中的作用尚不完全清楚。但大量研究表明PGD2通过相应受体介导参与哮喘的形成。最近，对于新型Th2细胞上表达的化学趋向性受体同种分子（chemoattractantreceptorhomologousmoleculeexpressedonTh2cells，CRTH2）受体的研究取得新进展，前列腺素类受体（dprostanoidreceptor，DP）与CRTH2两者协同作用诱导炎症细胞迁移和细胞因子的产生，介导哮喘等过敏性疾病的发生发展过程。该篇主要综述PGD2及其受体CRTH2在哮喘发病中作用机制的最新研究进展。
Prostaglandin D2 （PGD2） is a major prostanoid produced mainly by mast cells in allergic diseases,including bronchial asthma （asthma）. However, little was known of the role it plays in the pathophysiology of asthma. Recently, a novel and different receptor of PGD2, CRTH2, has been discovered. To date, DP and CRTH2 have been shown to be major PGD2-related receptors that have pivotal roles in mediating allergic diseases by effects such as directly regulating the migration of inflammatory cells and controlling the production of cytokines and lipid mediators. Available evidence suggests that CRTH2 and DP may collaborate in allergic inflammation. This review focuses on the novel roles of PGD2 and CRTH2 in the pathogenesis of asthma.
出处
《国际呼吸杂志》
2014年第5期354-359,共6页
International Journal of Respiration
