摘要
糖尿病患者甲状腺癌的发病风险明显增加,主要的危险因素包括胰岛素抵抗、肥胖、高血糖及高血脂、促甲状腺激素水平升高、降糖药物如胰岛素和磺脲类药物以及维生素D缺乏等.上述因素通过如胰岛素样生长因子-1、cAMP/蛋白激酶A及氧化应激等信号通路促进甲状腺癌的发生、发展.
The incidence of thyroid cancer in patients with diabetes is significantly increased,which happens possibly through insulin resistance,obesity,high blood glucose and high triglyceride,elevated levels of thyroid stimulating hormone （TSH）,antidiabetic therapy including insulin and sulfonylureas as well as vitamin D deficiency.All the above factors take part in the occurrence and development of thyroid cancer through different signal pathway such as insulin-like growth factor-1,cAMP/protein kinase A and oxidative stress.
出处
《国际内分泌代谢杂志》
北大核心
2014年第2期90-94,共5页
International Journal of Endocrinology and Metabolism
关键词
糖尿病
甲状腺癌
Diabetes mellitus
Thyroid cancer
