摘要
目的探讨妇炎康联合抗生素对慢性盆腔炎患者治疗效果,及血清中TNF-α、IL-1β、转化生长因子(TGF-β1)、IL-8表达的影响。方法 200例慢性盆腔炎患者随机分为2组,对照组给予左氧氟沙星治疗,治疗组给予妇炎康联合左氧氟沙星治疗,共21d,观察两组治疗前后主观症状改变,检测两组患者血清中TNF-α、IL-1β、TGF-β1、IL-8表达水平。结果治疗组主观症状改善显著,患者血清中TGF-β1表达增加,TNF-α、IL-8、IL-1β表达降低,与治疗前及对照组治疗后相比较有显著性差异(P<0.05);相关性分析表明IL-1β、IL-8、TNF-a与TGF-β1呈负相关(P<0.05)。结论妇炎康联合抗生素治疗慢性盆腔炎疗效显著,作用机制可能与减少炎症细胞因子浸润及炎症介质生成,促进炎细胞凋亡有关。
Objective To investigate the effect of Fuyankang and antibiotic in patients with chronic pelvic inflammatory disease,and the influence on the expression of serum TNF-α,IL-1β,transforming growth factor （TGF-β1）and IL-8. Methods 200 cases with chronic pelvic inflammatory disease patients were randomly divided into two groups by half,patients in control group were given levofloxacin,and patients in treatment group were given Fuyankang combined with levofloxacin,the course was 21 days,change of subjective symptoms was observed in both groups,and the expression level of serum TNF-α,IL-1β,TGF-β1,IL-8 were measured. Results In the treatment group subjective symptoms were significantly improved,serum TGF-β1 was increased and TNF-α,IL-8,IL-1βwere decreased,compared with before treatment and the control group after the treatment with significant difference （P〈0.05）.Correlation analysis revealed negative correlation between IL-1β,IL-8,TNF-a and TGF-β1（P〈0.05）. Conclusion Fuyankang and antibiotics treatment is effective in treating chronic pelvic inflammatory disease,the mechanism may be related to reduce inflammation cytokines infiltration and inflammatory medium generated,promote inflammation cell apoptosis.
出处
《中国医药科学》
2014年第3期71-73,共3页
China Medicine And Pharmacy
关键词
妇炎康
抗生素
慢性盆腔炎
炎症因子
Fuyankang
Antibiotics
Chronic pelvic inflammation
Inflammatory cytokines
