摘要
目的探讨脑源性神经营养因子Val66Met多态性与脑出血的关系。方法采用限制性内切酶片段长度多态性技术检测脑源性神经营养因子Val66Met多态性,在110例脑出血患者和101名健康对照组中的分布;比较病例组、对照组基因型、等位基因分布差异。结果 (1)脑出血组和对照组A基因型分布频率分别为0.40和0.20,显著高于对照组,差异具有统计学意义(x2=13.81,P=0.001);(2)两组等位基因分布频率差异也具有统计学意义,差异具有统计学意义(x2=13.12,P=0.000)。结论脑源性神经营养因子Val66Met多态性的A等位基因同脑出血相关,可能该病的易感基因。
Objective To explore the possible association between Va166Met polymorphism of BDNF and cerebral hemorrhage in Chinese Han population. Methods We analyzed polymorphisms of the BDNF Va166Met polymorphism with a lfragmentation length polymorphism（RFLP）-based method in 110 patients with cerebral hemorrhage and 101 unrelated healthy control subjects. Results （1）The AA genotypes frequencies of Va166Met polymorphism in cerebral hemorrhage patients and control subjects were 0.40 and 0.20,respectively,the difference was statistic（χ^2=13.81,P=0.001） （2）The allele frequencies of Va166Met polymorphism in cerebral hemorrhage and control group were significant（χ^2=13.12,P=0.000）.And the allele A frequency of Va166Met in cerebral hemorrhage patients was significantly higher than that of control subjects （P 〈 0.01）. Conclusion This study suggests that the BDNF Va166Met may be the major risk factors in increasing susceptibility to cerebral hemorrhage in Chinese Han population.
出处
《中国医药科学》
2014年第4期62-63,77,共3页
China Medicine And Pharmacy
关键词
脑源性神经营养因子
Val66Met
多态性
脑出血
Brain-derived neurotrophic factor（BDNF） gene
Va166Met
Polymorphism
Cerebral hemorrhage
