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足细胞病发病机制的研究进展——循环因子的作用和靶向治疗策略 被引量:4

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摘要 蛋白尿的发生不仅是肾脏损伤的显著标志,大量蛋白尿的持续存在还是预示肾脏病进展的重要因素.因此,蛋白尿水平是评估肾脏病疗效及预后的重要指标之一.传统的观点将肾小球滤过屏障简单地理解为3个层面的结构,目前认为至少由5层结构组成,由内而外分别是内皮细胞表面膜结构、内皮细胞及内皮细胞窗孔、肾小球基底膜(GBM)、足细胞下间隙和足细胞[1].足细胞是构成肾小球滤过膜的最后一道屏障,其功能受损已被证实是蛋白尿发生的关键环节.以足细胞损伤为突出表现的肾小球疾病被称为足细胞病,包括微小病变性肾病(MCD),局灶节段肾小球硬化(FSGS)和膜性肾病(MN),尤其以MCD和FSGS为足细胞病的代表.
作者 吕琴 罗惠民
出处 《临床肾脏病杂志》 2014年第2期68-71,共4页 Journal Of Clinical Nephrology
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同被引文献44

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