摘要
目的评价0.1%阿达帕林凝胶联合医用愈肤生物膜治疗痤疮炎性丘疹的疗效和安全性。方法采用开放的随机对照研究。按照通用标准选择炎性痤疮患者共95例,其中治疗组50例,对照组45例。治疗组早晨、傍晚各外敷一次医用愈肤生物膜,每次15min,夜间睡眠前外涂0.1%阿达帕林凝胶;对照组夜间睡眠前外涂0.1%阿达帕林凝胶。分别于初诊时、2周、4周、8周观察炎性丘疹的数量、不良反应(干燥、红斑、脱屑、灼热等)的情况。结果在治疗第4周时,治疗组有效率为66.00%,对照组为44.44%,差异有统计学意义(P=0.035);治疗8周时,治疗组有效率为94.00%,对照组为77.78%,差异有统计学意义(P=0.022);治疗组不良反应发生率为6.00%,对照组为22.22%,差异有统计学意义(P=0.008)。结论阿达帕林凝胶联合医用愈肤生物膜治疗痤疮炎性丘疹疗效显著,不良反应少。
Objective To evaluate the clinical efficacy and safety of 0. 1% adapalene gel combined medical skin healing biological film in the treatment of inflammatory papules of ance. Methods Open and randomized controlled study was used. A total of 95 patients with inflammatory papules of ance were enrolled into 2 groups. Fifty cases in treatment group which were treated by medical skin healing biological film in wet dressing for 15 minutes（twice daily in the morning and vesper）and 0.1% adapalene gel （once daily in the evening）. Forty-five cases in control group which were treated by 0.1% dapalene gel（ once daily in the evening）. All the patients received therapy for 8 weeks continuously and had been observed to evaluate the efficacy and safety on the second/fourth and eighth week of treatment. Results On the forth week of treatment, the total effective rate was 66. 00% in the treatment group and 44.44% in the control group （ P = 0. 035 ） ; on the eighth week,the figures were 94.00% and 77.78% respectively （P = 0. 022）. The rate of side-effect was 6.00% in the treatment group and 22.22% in the control group （ P = 0. 008 ）. Conclusion Adapalene gel combined medical skin healing biological film therapy is effective and safe in the treatment of inflammatory papules of ance.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第4期434-435,共2页
The Chinese Journal of Dermatovenereology
关键词
阿达帕林
医用愈肤生物膜
痤疮
炎性丘疹
Adapalene gel
Medical skin healing biological film
Ance
Inflammatory papules
