摘要
目的:探讨质子泵抑制剂在窄带成像内镜下氩离子凝固术治疗Barrett食管(BE)术后应用的疗效。方法:将120例经窄带成像内镜(NBI内镜)检查及病理确诊的BE食管患者随机分成A、B、C 3组,每组40例;3组均于NBI内镜下行氩离子凝固术(APC)治疗,术后均口服瑞巴派特片2周,其中B组术后同时予质子泵抑制剂以奥美拉唑口服治疗(20mg/次,2次/d,8周),C组术后予以奥美拉唑口服治疗(20mg/次,2次/d,8周后改为20mg/次,1次/d,口服36周);3组均于3,6,12个月进行NBI内镜复查,组间进行对比,评价3种方法治疗BE食管的疗效。结果:B、C组于治疗后3,6,12个月的治疗总有效率均高于A组(P<0.05),具有统计学差异;B、C组在治疗后3,6个月复查时治疗总有效率无显著差别(P>0.05),但12个月时C组治疗总有效率高于B组(P<0.05),差异有统计学意义。结论:Barrett食管行NBI内镜下APC治疗术后应行质子泵抑制剂长程维持治疗,可巩固治疗效果、降低BE黏膜复发。
Objective： To study the outcomes of proton pump inhibitors in Barrett＇s esophagus patients undergone argon plasma coagulation （APC） under narrow band imaging （NBI） endoscopy. Methods： A total of 120 cases confirmed by pathology received NBI endoscopy, and then were randomly and equally divided into three groups for rebamipide, rebamipide plus 8 weeks＇ omeprazole, and rebamipide plus 36 weeks＇ omeprazole treatment, respectively. The outcomes were evaluated under NBI endoscopy 3, 6, and 12 months respectively after operation. Results： Oral rebamipide plus omeprazole showed better effect than oral rebamipide only, meanwhile, after 12 months＇ follow-up, 36 weeks＇ omeprazole treatment showed better effect than 8 weeks＇ treatment （P〈0.05）. Conclusion： Long-term maintenance treatment of proton pump inhibitors shows better effect and less recurrence for Barrett＇s esophagus patients undergone argon plasma coagulation under NBI endoscopy.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2014年第2期318-320,324,共4页
Medical Journal of Wuhan University
