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自体造血干细胞移植联合伊马替尼治疗Ph染色体阳性急性淋巴细胞白血病16例临床观察 被引量：8

Outcome of autologous hematopoietic stem cell transplantation in combination with imatinib for 16 cases of Philadelphia chromosome positive acute lymphoblastic leukemia
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摘要 费城染色体阳性（Ph^＋）或BCR-ABL融合基因阳性见于20％-40％的成人和2％～7％的儿童急性淋巴细胞白血病（ALL）患者，不仅是ALL最常见的分子学异常，也是预后最差的亚型之一。
作者 刘欣 姜尔烈 黄勇 杨栋林 庞爱明 魏嘉璘 马巧玲 张荣莉 邱录贵 冯四洲 韩明哲
机构地区 中国医学科学院、北京协和医学院血液学研究所、血液病医院
出处 《中华血液学杂志》 CAS CSCD 北大核心 2014年第3期250-252,共3页 Chinese Journal of Hematology
基金 国家科技（重大新药创制）专项（2011zx09302.007.04） 天津市应用基础与前沿技术研究计划（10JCYBJC13100） 卫生公益性行业科研专项（201202017）
关键词 儿童急性淋巴细胞白血病 PH染色体阳性 自体造血干细胞移植 临床观察 伊马替尼 BCR-ABL融合基因 治疗 费城染色体
分类号 R733.71 [医药卫生—肿瘤]
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参考文献8

  • 1Fielding AK, Rowe JM, Richards SM, et al. Prospective out- come data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms su- periority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC KALLXII/ECOG2993 [ J ] Blood, 2009,113(19):4489-4496.
  • 2Dombret H, Gabert J, Boiron JM, et al. Outcome of treatment in adults with Philadelphia chromosome- positive acute lymphoblastic leukemia--results of the prospective multicenter LALA-94 trialE J ]. Blood, 2002, 100 (7) :2357-2366.
  • 3Mizuta S, Kohno A, Morishita Y, et al. Long-term follow-up of 14 patients with philadelphia chromosome-positive acute lymphoblastic leukemia following autologous bone marrow transplantation in first complete remission [J]. Int J Hematol, 2007, 85(2):140-145.
  • 4Yanada M, Takeuchi J, Sugiura I, et al. High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group[J]. J Clin Oncol, 2006, 24(3 ):460-466.
  • 5Lee S, Kim Y J, Chung NG, et al. The extent of minimal residual disease reduction after the first 4-week imatinib therapy deter- mines outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leu- kemia[J]. Cancer, 2009,115(3):561-570.
  • 6Chen H, Liu KY, Xu LP, et al. Administration of imatinib after allogeneic hematopoietic stem cell transplantation may improve disease-free survival for patients with Philadelphia chromosome- positive acute lymphobla stic leukemia [J]. J Hematol Oncol, 2012,5:29.
  • 7Tanguy-Schmidt A, Rousselot P, Chalandon Y, et al. Long-term follow-up of the imatinib GRAAPH-2003 study in newly diag- nosed patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: a GRAALL stud[J]. Biol Blood Marrow Transplant, 2013,19( 1 ): 150-155.
  • 8Bassan R, Rossi G, Pogliani EM, et al. Chemotherapy-phased imatinib pulses improve long-term outcome of adult patients with Philadelphia chromosome-positive acute lymphoblastic leu- kemia: Northern Italy Leukemia Group protocol 09/00 [J]. J Clin Oncol, 2010,28 (22) :3644-3652.

同被引文献73

  • 1靳凤艳,邹德慧,王国蓉,徐燕,冯四洲,赵耀中,韩明哲,严文伟,邱录贵.成人急性淋巴细胞白血病缓解后化疗和自体造血干细胞移植疗效的比较[J].中华血液学杂志,2005,26(11):645-648. 被引量：17
  • 2Alvarado Y, Apostolidou E, Swords R, et al. Emerging therapeutic options for Philadelphia-positive acute lymphocytic leukemiaIJ]. Expert Opin Emerg Drugs, 2007, 12( 1 ): 165-179.
  • 3Fielding AK, Rowe JM, Richards SM, et al. Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome - positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC UKALLXII/ECOG2993 E J ]. Blood, 2009, 113 (19) 4496. 4489-.
  • 4Giebel S, Labopin M, Gorin NC, et al. Improving results of autologous stem cell transplantation for Philadelphia-positive acute lymphoblastic leukaemia in the era of tyrosine kinase inhibitors: a report from the Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation [J].Eur J Cancer, 2014, 50(2):411-417.
  • 5Yanada M, Takeuchi J, Sugiura I, et al. High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group~J]. J Clin Oncol, 2006, 24(3 ):460-466.
  • 6Labarthe A, Rousselot P, Huguet-Rigal F, et al. Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the GRAAPH-2003 study [J]. Blood, 2007.109(4):1408-1413.
  • 7Ribera JM. Optimal approach to treatment of patients with Phila- delphia chromosome-positive acute lymphoblastic leukemia: how to best use all the available tools [J]. Leuk Lymphoma, 2013, 54( 1 ): 21-27.
  • 8Mizuta S, Matsuo K, Yagasaki F, et al. Pre-transplant imatinib- based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR-ABL-positive acute lymphoblastic Leukemia [ J ]. Leukemia, 2011, 25 ( 1 ) :41- 47.
  • 9Lee S, Kim Y J, Chung NG, et al. The extent of minimal residual disease reduction aider the first 4-week imatinib therapy determines MRD kinetics in Ph-positive ALL transplants outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia EJI. Cancer, 2009, 115(3) :561-570.
  • 10Mizuta S, Matsuo K, Nishiwaki S, et al. Pretransplant administration of imatinib for allo-HSCT in patients with BCR- ABL-positive acute lymphoblastic leukemia EJ~. Blood, 2014, 123 (15) :2325-2332.

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中华血液学杂志
2014年 第3期

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