摘要
目的观察不同时机启动肠内营养(EN)对重症急性胰腺炎(SAP)大鼠模型胰腺和肠道的病理学影响并初步探讨机制。方法将84只SD大鼠建立SAP模型,随机分为肠外营养组(PN组)21只和肠内营养组(EN组)63只。其中PN组21只大鼠采用肠外营养支持治疗;EN组63只大鼠采用肠内营养治疗,根据EN启动时间不同分为ENⅠ组(第2天)、ENⅡ组(第4天)和ENⅢ组(第6天)三组;比较各组不同时间胰腺病理学评分和肠道病理学改变。结果治疗后EN组胰腺病理评分显著低于PN组(P<0.01),EN组内各组之间评分差异也有显著性(P<0.05);EN比PN能更好地保护胰腺组织和肠道黏膜,EN启动越早效果越好。结论 EN可以改善SAP大鼠模型胰腺和肠道病理学状况,EN启动越早恢复越快。
Objective To explore the pathological effect and mechanism of enteral nutrition at different time on pancreas and intestinal tract of rats with severe acute pancreatitis. Methods 84 rats were used to establish SAP model,and divided into two groups,the PN group（21 cases） received routine treatment by parenteral nutrition,the EN group was randomly divided into 3 subgroups（21 cases in each group）,received EN at different time（the second day,the fourth day,the sixth day）,to compare the pathological score of pancreas and intestinal tract. Results Compared with the PN group,the pathological score in EN group is lower（P〈0.01）,and it is also different in the EN subgroups（P〈0.05）;the EN is in favor of the intestinal tract,more earlier more better. Conclusion The enteral nutrition can improve the pathological situation of pancreas and intestinal tract,more earlier more sooner.
出处
《中南医学科学杂志》
CAS
2014年第1期36-39,共4页
Medical Science Journal of Central South China
基金
湖南省教育厅医学科研项目资助(09C848)
衡阳市科技局资助项目(2011KJ51)
关键词
肠内营养
重症急性胰腺炎
病理学
enteral nutrition
severe acute pancreatitis
pathobiology
