摘要
后囊膜混浊(PCO)是白内障术后影响视力恢复的主要并发症,其发生的主要生物学基础是术后前囊膜周边部和赤道部残留的晶状体上皮细胞增殖、移行并化生为成纤维样细胞。成纤维细胞生长因子(FGFs)及其受体(FGFRs)通过参与调节晶状体上皮细胞的增殖、移行和转化过程,而在PCO的形成中发挥关键性作用。该文就FGFs及FGFRs的分子生物学、PCO形成中的作用及其应用等研究进展予以综述。
Posterior capsule opacification（PCO） is the major complication that affects the visual acuity restoration after cataract surgery Its main biological basis is the postoperative proliferation, migration and met- aplasia of residual lens epithelial cells on the peripheral part and the equator of anterior capsule into fibro- blast-like cells. Fibroblast growth factors（FGFs） and their receptors （FGFRs）, involved in the regulation of the proliferation, migration, and metaplasia of lens epithelial cells, play a crucial role in the formation of PCO. Here is to make a review of the progress in the FGFs and FGFRs molecular biology,their effects on the formation of PCO and their applications.
出处
《医学综述》
2014年第5期775-778,共4页
Medical Recapitulate
基金
广西自然科学基金(桂科自0899004)
