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波叶山蚂蝗α-葡萄糖苷酶抑制活性研究

α-Glucosidase Inhibitory Activity of Extracts from Desmodium sequax
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摘要 目的:评价波叶山蚂蝗提取物对α-葡萄糖苷酶的抑制活性。方法:通过建立体外α-葡萄糖苷酶抑制模型,对波叶山蚂蝗石油醚、乙酸乙酯、正丁醇提取物进行活性筛选。结果:波叶山蚂蝗3个提取物均有较好的α-葡萄糖酶抑制作用,抑制活性均远远大于阳性对照阿卡波糖(IC50=1 103.01 mg·L-1),其中以石油醚部位(DSPE)活性最好(IC50=45.16 mg·L-1)。乙酸乙酯部位(DSEA)和正丁醇部位(DSME)对α-葡萄糖苷酶抑制活性呈显浓度依赖性。结论:波叶山蚂蝗3个提取部位有较显著的α-葡萄糖苷酶抑制活性,具有开发应用的价值。 Objective: To evaluate α-glucosidase inhibitory activity of extracts from Desmodium sequax. Method: By establishing α-glucosidase inhibitory model in vitro, the activity of petroleum ether extract, ethyl acetate extract and methanol extract from D. sequax was screened. Result: Three extracts from D. sequax showed good inhibitory activity, which showed far greater activity than that of acarbose (IC50=1 103.01 mg·L^-1). Petroleum ether extract (DSPE) had the highest inhibitor activity (IC50=45.16 mg·L^-1). α-glucosidase inhibitory activity of ethyl acetate extract (DSEA) and methanol extract (DCME) had concentration-dependent. Conclusion: Three extracts had more significant α-glucosidase inhibitory activity and great development and application value.
出处 《中国实验方剂学杂志》 CAS 北大核心 2014年第7期70-72,共3页 Chinese Journal of Experimental Traditional Medical Formulae
基金 贵州省中药现代化项目(黔科合中药字[2010]5029) 教育部春晖计划项目(Z2011036) 贵阳市科技计划项目(2012204)
关键词 波叶山蚂蝗 Α-葡萄糖苷酶 抑制活性 Desmodium sequax α-glucosidase inhibitory activity
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