摘要
氨基糖苷类抗生素是较早被发现并应用于临床上的一类抗生素,虽然它们没有完全从市面上消失,但由于其他副作用较少且广谱的抗生素的出现,其重要性已经减弱。目前,随着由多药耐药性(MDR)细菌引起的感染急剧增加,作为为数不多的治疗选择,氨基糖苷类抗生素重新进入了人们的视野,特别是用于革兰氏阴性细菌感染。尽管病菌对氨基糖苷类抗生素的耐药机制已基本清楚,但对氨基糖苷类抗生素抗菌模式的认识还远未全面。面对越来越多几乎无法治疗的细菌感染,氨基糖苷类抗生素在对抗多药耐药性病原菌上显示出新的应用前景。
Aminoglycoside antibiotics are a kinds of early discovered and applied clinical antibiotics. Although they have not completely disappeared from the market, along with the emergence of broad spectrum antibiotics with fewer side effects, its importance has diminished. At present, due to the infection caused by multidrug resistant （MDR） bacteria increased dramatically, as one of the few treatment options, aminoglyeoside antibiotics are back to peoples vision, especially for Gram- negative bacterial infection. Although their resistance mechanism has been basically clear, the understanding of antibacterial mode is far from comprehensive. Facing more and more virtually untreatable infections, this kind of old antibiotics would have application potential to combat multi-drug resistant pathogens.
出处
《生物技术进展》
2014年第2期102-106,共5页
Current Biotechnology
关键词
氨基糖苷类抗生素
多药耐药性
革兰氏阴性细菌
抗菌模式
aminoglycoside antibiotics
muhidrug-resistant
Gram-negative pathogens
antimicrobial mode
