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CaO-SiO_2/PAA复合膜的制备及其体外生物活性

Synthesis and in vitro Bioactivity of CaO-SiO_2/PAA Composite Film
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摘要 以四水合硝酸钙为钙源、正硅酸乙酯为硅源(按CaO/SiO2摩尔比1∶1),采用溶胶-凝胶法制备出CaO-SiO2生物玻璃溶胶.采用压力诱导的方法将CaO-SiO2溶胶注入多孔阳极氧化铝(PAA)的纳米孔道中,经550℃热处理,得到CaO-SiO2/PAA复合膜.所得样品在模拟体液(SBF)中分别浸泡1和7d,观察其表面诱导形成类骨磷灰石的能力.通过扫描电镜(SEM)、X射线能谱仪(EDS)、傅里叶变换红外衍射仪(FTIR)对浸泡前后样品的微观形貌和成分进行表征.试验结果表明:钙硅基生物活性材料能够装载在PAA的纳米孔道中,并且装载有钙硅基材料的PAA在SBF中浸泡后能诱导类骨磷灰石的生成. CaO-SiO2 sols were prepared by a sol-gel technique using reagent-grade calcium nitrate tetrahydrate (Ca(NO3)2 ~ 4H20) and tetraethoxysilane (TEOS, Si(OC2Hs)~) as precursors with an initial CaO to SiO2 molar ratio of 1 ." 1. The CaO-SiO2 sols were then filled into the nano-pores of porous anodic alumina (PAA) by a pressure-induced technique under vacuum. After heat treatment at 550 ~C, the CaO-SiO2/PAA composite film was obtained. The in vitro apatite formation ability of the samples was investigated by soaking them in simulated body fluid (SBF) for J day and 7 days respectively. The microstructure and chemical composition of the samples before and after soaking were analyzed by means of scanning electron microscope (SEM), X-ray energy dispersive spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR). The results indicated that the nano-porous structure of PAA could be loaded with CaO-SiO2 bioactive materials and the CaO-SiO2/PAA composite film could induce bone-like apatite formation on its surface.
出处 《东华大学学报(自然科学版)》 CAS CSCD 北大核心 2014年第1期71-75,82,共6页 Journal of Donghua University(Natural Science)
基金 国家自然科学基金资助项目(50902020)
关键词 CaO-SiO2 多孔阳极氧化铝(PAA) 模拟体液(SBF) 类骨磷灰石 CaO-SiO2 porous anodic alumina (PAA) simulated body fluid (SBF) CaO-SiO2 porous anodic alumina (PAA) simulated body fluid (SBF) bone-like apatite
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参考文献19

  • 1LEE W, J1 R, GOSELE U, et al. Fast fabrication of long- range ordered porous alumina membranes by hard anodization [J]. Nature Materials, 2006, 5(9) :741-747.
  • 2CU1 J W, WU Y C, WANG Y. A facile and efficient approach for pore opening detection of anodic aluminum oxidememhranes [J]. Applied Surface Science, 2012, 258(14): 5305-5311.
  • 3SINGH G K, GOLOVIN A A, ARANSON I S. Formation of self organized nanoscale porous structures in anodic aluminum oxide [J]. Physical Review B, 2006, 73(20): 205422-205433.
  • 4O'SULI.IVAN J P, WOOD G C. The morphology and mechanism of formation of porous anodic films on aluminum[C]// Proceedings of the Royal Society of London. Series A, Mat hematical and Physical Sciences, 1970,317 ( 1531 ) : 511 - 543.
  • 5KARLSSON M, PALSGARD E, WILSHAW P R, et al. Initial in vitro interaction of osteoblasts with nano-porous alumina[J]. Biomaterials, 2003, 24(18): 3039-3046.
  • 6CHUNGS H, SON S J, MIN J. The nanostructure effect on the adhesion and growth rates of epithelial cell with well- defined nanoporous alumina substrates[Jl. Nanotechnology, 2010, 21(i2) :125104.1-125104.7.
  • 7HU J, TIAN J H, CHEN Y, et al. Cell culture on AAO nanoporous substrated with and without geometry constrains [J]. Microelectronic Engineering, 2011, 88(8): 1714-1717.
  • 8WALPOLE A R, XlA Z D, WILSON C W, et al. A novel nano porous alumina biomaterial with potential for loading with bioactive materials [J ] Journal of Biomedical Materials Research Part A, 2009, 90(1): 46-54.
  • 9万祥辉,常程康,毛大立.化学沉淀法制备纳米硅酸钙及其在模拟体液中的活性行为[J].材料科学与工程学报,2005,23(2):230-234. 被引量:10
  • 10朱宏扬,尹光福,吴江,陈显春.溶胶-凝胶法制备硅酸钙及其体外生物活性的研究[J].生物医学工程研究,2008,27(1):9-12. 被引量:5

二级参考文献21

  • 1林开利,常江,汪正.多孔硅酸钙生物陶瓷的制备及体外活性和降解性研究[J].无机材料学报,2005,20(3):692-698. 被引量:21
  • 2范恩荣.硅灰石的应用和人造硅灰石的制备[J].矿产保护与利用,1996,16(4):17-20. 被引量:12
  • 3王志强,胡继林,刘晓蕾,陈晓旭,吕秉玲.硅酸钙-磷酸盐复合骨水泥的制备及其性能研究[J].生物医学工程学杂志,2006,23(1):121-124. 被引量:6
  • 4[9]Kokubo T,Kushitani H,Sakka S,et al.Solutions able to reproduce in vivo surface changes in bioactive glass-ceramic A-W3[J].J Biomed Mater Rea,1990,24:721-724.
  • 5[10]ISO Document 10993-5:1992,Biological evaluation of medical devices:part 5.Tests for cytotoxicity:in vitro methods[S].
  • 6Gou ZG, Chang J. Synthesis and in vitro bioactivity of dicalcium silicate powders[J]. Journal of the European Ceramic Society, 2004,24:93 ~ 99.
  • 7Salinas AJ, Vallet-Regi M, Izquierdo-barba I. Biomimetic apatite deposition on calcium silicate gel glasses [J]. Journal of Sol-Gel Science and Technology,2001, 21:13 ~ 25.
  • 8Kokubo T, Ito S, Huang Z, Hayashi T, Sakka S, Kitsugi T,Yamamuro T. Ca-P-rich layer formed on high-strength bioactive glassceramic A-W [J]. J Biomed Mater Res, 1990, 24:331 ~ 43.
  • 9Liu XY, Ding CX. Plasma sprayed wollastonite/TiO2 composite coating on Titanium alloys [J]. Biomaterials, 2002, 23:4065 ~4077.
  • 10Liu XY, Ding CX. Plasma-sprayed wollastonite 2M/ZrO2 composite coating [J]. Surface and Coatings Technology, 2003, 172:270 ~278.

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