摘要
目的探讨原发性系统性淀粉样变性（AL）患者行自体外周血造血干细胞采集中的护理要点。方法 13例AL患者在本科干细胞移植病房行自体外周血造血干细胞采集,所有患者均经肾活检明确诊断,采用单用粒细胞刺激因子（G-CSF）方案采集干细胞,人均采集2次。结果所有患者均成功采集足够干细胞,主要并发症为低钙血症、低钾血症及血小板减低。采集CD34＋细胞数（2.00~8.36）×106/kg,平均（4.02±2.01）×106/kg。结论对于严格选择的AL患者,自体外周血干细胞移植（AHSCT）治疗是一种有效的治疗手段,采集足量的造血干细胞是成功行干细胞移植的重要前提。
Objective To summarize important nursing experience of autologous peripheral hematopoietic stem cell collection of patients with primary systemic amyloidosis（AL）. Methods A total of 13 patients with AL in the ward of hematopoietic stem cell transplantation were conducted peripheral hematopoietic stem cell collection, and all the patients were definitely diagnosed by renal biopsy. The method of granulocyte stimulating factor（G-CSF）was applied to collect stem cells with twice per capita. Results Sufficient stem cells were successfully collected in all patients. The major complications of patients were hypocalcemia, hypokalemia and thrombocyte reduction. The number of CD34＋ cells collected was（2.00~ 8.36）× 106/kg with（4.02± 2.01）× 106/kg for each cell in average. Conclusion Autologous hematopoietic stem cell transplantation is an effective curative method forALpatients,and adequate hematopoietic stem cells collection is an important prerequisite for the success of stem cell transplantation.
出处
《实用临床医药杂志》
CAS
2014年第2期6-9,共4页
Journal of Clinical Medicine in Practice
