摘要
植物受体激酶BAK1在多个信号转导路径上独立的多角色功能,成为拟南芥受体激酶610个成员中最受关注的成员之一。BAK1是一个典型的富亮氨酸重复序列的跨膜受体激酶,属于LRR-RKⅡ家族,在结构上由胞外结合域、跨膜区以及胞内激酶结构域三部分构成。最初BAK1被鉴定为BRI1和FLS2的双元受体,分别参与调控植物油菜素内酯BR的信号转导及病原相关模式分子PAMPs引发的免疫反应,近期又有多个BAK1的互作组分被相继发现,如EFR、AvrPto、PEPR1/2、PUB13、BIR1、BON1等。该文从BAK1的分子结构,BAK1所在SERKs家族的功能冗余,对油菜素内酯路径的信号调控,参与病菌识别防御反应的先天免疫和调控细胞凋亡等方面对近年来国内外的相关研究进展进行综述,以明确目前研究所面临的问题。
Receptor kinse BAK1 （BRI-Associated Kinase 1） has been highlighted among all of 610 RKs oi Arabidopsis thaliana because it played different independent roles in multiple signal transduction path- ways. BAK1 is a typical leucine-rich repeats receptor kinase（LRR-RK） that belongs to the LRR-RK Ⅱ fam- ily and structurely composed with three parts named extracellular domain,transmembrane domain and in- tracellular kinase domain. BAK1 was firstly identified as a dual co-receptor of BRI1 and FLS2,mediating BR signaling and pathogen-associated molecular pattern （PAMP） triggered immunity （PTI） in plant, re- spectively. Additionally,a set of new BAK1- interaction protein components,such as EFR,AvrPto,PEPR 1/2,PUB13,BIR1,BON1,have been uncovered recently. This work has comprehensively reviewed the re- cently research progress on the molecular structure of BAK1, function-redundance of SERK, the role of BAK1 involving in BR signaling and PTI,as well as cell death,and expectively to clarify the research ques tions presently faced.
出处
《西北植物学报》
CAS
CSCD
北大核心
2014年第3期636-644,共9页
Acta Botanica Boreali-Occidentalia Sinica
基金
国家自然科学基金(C120106)
