摘要
目的:探讨影响结核病感染患者预后的相关因素。方法:选取本院2010年1月至2013年12月收治的肺结核感染患者84例为研究对象,采用单因素分析影响肺结核患者预后的相关因素,同时采用Cox回归分析患者预后独立危险因素,并采用Kaplan-Meier法计算患者累计生存率。结果:经单因素分析可知,影响肺结核患者预后的因素包括呼年龄、患病时间、吸烟、是否行机械通气、是否接受规则抗结核治疗、呼吸衰竭II型、APACHEII>25分、肝损害、合并真菌感染、合并基础疾病。经Cox多因素回归分析可知,呼吸衰竭II型(OR=3.066,95%CI 1.021-7.298))、APACHEII>25分(OR=1.984,95%CI 1.021-5.201)、合并真菌感染(OR=1.658,95%CI 1.187-3.964)、肝损害(OR=1.587,95%CI 1.085-3.412)、合并基础疾病(1.623,95%CI 1.045-4.369)是影响患者预后的独立危险因子。结论:影响结核感染疾病预后的因素包括呼吸衰竭II型、APACHEII>25分、合并真菌感染、肝损害,这些因素可增加患者病死率,降低患者生存质量。
Objective：To investigate the factors that impact the prognosis of patients with tuberculosis infection.Methods： 84 cases of tuberculosis were selected in our hospital from January 2010 to December 2013. The prognostic factor of all patients were analysised with single-factor analysis and Cox regression analysis and the cumulative survival rate were calculated with Kaplan-Meier method.Results：The respiratory age, duration of disease, smoking, whether mechanical ventilation, whether to accept the rules of anti-TB treatment, type II respiratory failure, APACHEII〉25 points, liver damage, combined fungal infections, underlying diseases were the single-factor which impact on the prognostic of patients. he type II respiratory failure （OR=3.066,95%CI 1.021-7.298））, APACHEII〉25 （OR=1.984, 95%CI 1.021-5.201）, fungal infection （OR=1.658, 95%CI 1.187-3.964）, liver damage （OR=1.587,95%CI 1.085-3.412）, underlying diseases （1.623, 95%CI 1.045-4.369） were the prognostic independent risk factor with Cox multivariate regression analysis. Conclusion：The factors affecting the prognosis are respiratory failure type II APACHEII〉25,fungal infections, liver damage, these factors can increase the mortality of patients, reduce the quality of life of patients.
出处
《中国医药导刊》
2014年第1期40-41,43,共3页
Chinese Journal of Medicinal Guide
关键词
肺结核
预后因素
病死率
Tuberculosis
Prognostic factors
Mortality
