摘要
[目的]研究祛湿化瘀方治疗非酒精性脂肪肝患者的临床疗效及其对相关生化指标的影响.[方法]使用随机数字表法将我院2010年1月～2012年12月期间收治的80例非酒精性脂肪肝患者分为对照组44例和治疗组36例,对照组给予多烯磷脂酰胆碱胶囊2粒/次,3次/d;治疗组给予祛湿化瘀方,1剂/d.2个月后统计疗效,检测患者的肝功能和血脂水平,并记录患者的症状评分和不良反应情况.[结果]治疗组总有效率为91.7％,明显优于对照组（72.7％）,差异有统计学意义（P＜0.05）;经治疗后两组患者的ALT、AST、TC和TG均有下降,与治疗前相比差异均有统计学意义（P＜0.05）;两组患者症状评分均有明显改善（P＜0.05）,治疗组的改善更佳,其中胁肋疼痛和便溏两症状与对照组比较差异有统计学意义（P＜0.05）;治疗组不良反应发生率与对照组相比差异不显著.[结论]祛湿化瘀方治疗非酒精性脂肪肝患者的临床疗效确切,能够明显降低血脂,其症状改善优于多烯磷脂酰胆碱,值得临床推广.
[Objective]To investigate the clinical effects of Qushi Huayu decoction on patients with non alcoholic fatty liver disease（NAFLD）.[Methods] Eighty patients with NAFLD from January 2010 to December 2012 were randomly divided into control group with 44 cases and treatment group with 36 cases.The control group was given polyene phosphatidylcholine capsules 2 pills per time and three times a day,while the treatment group was given Qushi Huayu decoction 1 dose per day.Curative effect,liver function,level of blood lipid,symptom score and adverse reaction were recorded after 2 months.[Results] Total effectiveness of treatment group（91.7％） was obviously better than control group（72.7％）（P＜0.05）.Compared with before treatment,the levels of ALT,AST,TC and TG in both groups were decreased significantly after treatment （P＜0.05）.Symptom scores of two groups were improved significantly （P＜0.05）.The amelioration of rib pain and loose stool of the treatment group was better than control group and the difference was statistically significant （P＜0.05）,Rate of adverse reaction in treatment group was similar to the control group.[Conclusion] The treatment of NAFLD with Qushi Huayu decoction has good clinical curative effects and safety.It can reduce blood lipid significantly,and is superior to polyene phosphatidylcholine in improving symptoms,which is worth wide clinical appilication.
出处
《中国中西医结合消化杂志》
CAS
2014年第3期139-142,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
非酒精性脂肪肝
祛湿化瘀方
多烯磷脂酰胆碱
症状评分
non-alcoholic fatty liver disease
Qushi Huayu decoction
polyene phosphatidylcholine
symptom score
