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miR-150与临床疾病研究的新进展 被引量：19

New advances of miR-150 and diseases
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摘要 microRNA(miRNA)是一种新型的小分子非编码RNA,对基因表达具有非常重要的调控作用。miR-150是一个长度为22个核苷酸的非编码小分子RNA,定位于人类染色体19q13.33,主要通过调控其靶基因的表达,在免疫系统、造血系统发生、胚胎发育和干细胞分化中发挥重要作用,并在许多疾病中发生异常表达,提示miR-150与疾病的发生与发展密切相关。本文就miR-150在人体正常生理过程中的作用以及异常表达引起的机体变化和可能的作用机制作一综述。 MicroRNA （miRNA）is a novel type of non-coding RNA which can play very important roles in regulating gene expression. Early studies found that miR-150 is a 22 nt non-coding RNA, and located on Chromosome 19. It plays key roles in immune system, hematopoietic system progressive, embryonic development and stem cells differention by regulating the expression of its target mRNA. Recent investigations suggest that miR-150 expresses abnormally in different diseases. This reveals that miR-150 is closed related to the occurrence and development of many diseases. This article reviews the effect of miR-150 in human normal physiological processes, its abnormal expressions inducing changes in body and the possible mechanism involved.
作者 刘付梅 李祥勇 周克元
机构地区 广东医学院生物化学与分子生物学研究所
出处 《医学研究生学报》 CAS 北大核心 2014年第2期194-198,共5页 Journal of Medical Postgraduates
基金 国家自然科学基金(81172067) 东莞市高等院校科技计划一般项目(2011108102044) 湛江市科技攻关项目(2011C3108012)
关键词 miR-150 临床疾病 基因表达调控 miR-150 Clinical disease Gene expression regulation
分类号 Q344.13 [生物学—遗传学]
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参考文献28

  • 1Tokarz P,Blasiak J.The role of MiRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment[J].Acta Biochim Pol,2012,379(59): 1-8.
  • 2Varma SD,Kovtun S.Protective effect of caffeine against high sugar-induced transcription of microRNAs and consequent gene silencing: A study using lenses of galactosemic mice[J].Mol Vis,2013,19: 493-500.
  • 3张向君,王加林.MicroRNA-143在肥胖及胰岛素抵抗中的研究进展[J].医学研究生学报,2013,26(6):666-668. 被引量：6
  • 4Zhou B,Wang S,Mayr C,et al.MiR-150,a microRNA expressed in mature B and T cells,blocks early B cell development when expressed prematurely[J].Proc Natl Acad Sci USA,2007,104(17): 7080-7085.
  • 5Li J,Zhang Y,Liu Y,et al.Microvesicle-mediated transfer of miR-150 from monocytes to endothelial cells promotes angiogenesis[J].J Biol Chem,2013,288(32): 23586-23596.
  • 6Lin YC,Kuo MW,Yu J,et al.c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development[J].Mol Biol Evol,2008,25(10): 2189-2198.
  • 7Tano N,Kim HW,Ashraf M.MicroRNA-150 Regulates Mobilization and Migration of Bone Marrow-Derived Mononuclear Cells by Targeting Cxcr4[J].PloS One,2011,6(10): e23114.
  • 8Fallah P,Arefian E,Naderi M,et al.miR-146a and miR-150 promote the differentiation of CD133(+) cells into T-lymphoid lineage[J].Mol Biol Rep,2013,48(8): 4713-4719.
  • 9Wu Q,Jin H,Yang Z,et al.MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2[J].Biochem Biophys Res Commun,2010,392(3): 340-345.
  • 10Watanabe A,Tagawa H,Yamashita J,et al.The role of microRNA-150 as a tumor suppressor in malignant lymphoma[J].Leukemia,2011,25(8): 1324-1334.

二级参考文献60

  • 1韩瑜,韩变梅,柳明洙,陈曦.心肌胶原及代谢[J].中国循环杂志,2006,21(4):315-317. 被引量：13
  • 2Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest, 1992,101 : 1644-1655.
  • 3Ambros V. The functions of animal microRNAs. Nature, 2004,431 : 350-355.
  • 4O' Connell RM, Taganov KD, Boldin MP, et al. MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci USA ,2007,104 : 1604-1609.
  • 5Taganov KD, Boldin MP, Chang KJ, et al. NF-KB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling protein of innate immune responses. Proc Natl Acad Sci USA ,2006, 103 : 12481-12486.
  • 6Dai R, Phillips RA, Zhang Y, et al. Suppression of LPS-induced interferongamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation. Blood ,2008,112:4591-4597.
  • 7Chen C, RidzonDA, Broomer A, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res ,2005,33 :e179.
  • 8Pedersen I, David M. MieroRNAs in the immune response. Cytokine,2008,43 : 391-394.
  • 9Tili E, Michaille JJ, Cimino A,et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol,2007 ,179 :5082-5089.
  • 10Vasilescu C, Rossi S, Shimizu M, et al. MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS One. 2009,4:e7405.

共引文献29

同被引文献92

  • 1陈少安,孟慧林.特拉唑嗪联合治疗前列腺炎的研究进展[J].泌尿外科杂志（电子版）,2013,5(4):1-3. 被引量：1
  • 2周海燕,李勇,文继舫.miR-155的研究进展[J].现代生物医学进展,2009,9(24):4778-4782. 被引量：3
  • 3Ming Gao,Hao Yin,Zhe-Wei Fei.Clinical application of microRNA in gastric cancer in Eastern Asian area[J].World Journal of Gastroenterology,2013,19(13):2019-2027. 被引量：16
  • 4Zheng Q1, Zhou L, Mi QS. MicroRNA miR-150 is in- volved in V~14 invariant NKT cell development and func- tionEJ~. J Immunol, 2012,188(5): 2118 - 2126.
  • 5Michael MZ, O'Connor SM, van Hoist Pellekaan NG, et al. Re- duced accumulation of specific microRNAs in colorectal neoplasia [ J]. Mol Cancer Res, 2003,1 (12) :882-891.
  • 6Zhou L, Qi X, Potashkin JA, et al. MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3 '-untranslat- ed region of the gene that decrease steady-state levels of the tran- script[J]. J Biol Chem, 2008,283(42) :28274-28286.
  • 7Pasquinelli AE. MieroRNAS and their targets : recognition, regn|a- tion and an emerging reciprocal relationship [ J ]. Nat Rev Genet, 2012,13 (4) :271-282.
  • 8Cunningham D, Atkin W, Lenz HJ, et al. Colorectal cancer[ J]. Lancet, 2010,375(9719) :1030-1047.
  • 9Zhou B, Wang S, Mayr C, et al. miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when ex- pressed prematurely[J]. Proc Natl Acad Sci U S A, 2007,104 ( 17 ) :7080-7085.
  • 10Cheng AM, Byrom MW, Shehon J, et al. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis [ J ]. Nucleic Acids Res, 2005,33 ( 4 ) : 1290-1297.

引证文献19

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医学研究生学报
2014年 第2期

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