摘要
目的 比较多巴胺与去甲肾上腺素治疗休克的临床疗效及两者对肾功能的影响.方法 选取休克患者100例,按数字表法随机分为去甲肾上腺素组和多巴胺组,每组50例,接受其他抗休克治疗的同时分别应用去甲肾上腺素和多巴胺进行治疗.观察指标为第7天患者病死率及治疗前、治疗后12 h、72 h的BUN值和肌酐（CRE）值.结果 两组患者第7天的病死率差异无统计学意义（x2=0.765,P＞0.05）.但多巴胺组心律失常发生率为34％,显著高于去甲肾上腺素组的16％（x2=3.84,P＜0.05）.治疗后,两组BUN和CRE均有所恢复,但都略高于正常值,去甲肾上腺素组更接近正常值.结论 应用去甲肾上腺素与多巴胺治疗休克的临床疗效相当,但去甲肾上腺素比多巴胺更能有效地改善肾功能.
Objective To compare the effect of dopamine and norepinephrine in the treatment of shock and the effect on renal function. Methods 100 shock patients were randomly divided into norepinephrine group and dopa- mine group, 50 cases in each group. On the basis of other anti-shock treatment, norepinephrine or dopamine was used in group A and group B. The mortality of the 7th day and urea nitrogen（ BUN）, creatinine values （CRE） 12h, 72h after treatment were observed. Results There was no significant difference between two groups in the 7th day mortality （ X2 = 0.765, P 〉 0.05 ）. However, the proportion of arrhythmia in dopamine group was 34%, which was significantly higher than the norepinephrine group （ 16% ） （ X2 = 3.84, P 〈 0.05 ）. After treatment, the BUN and CRE levels in both two groups recovered, the norepinephrine group recovered better than the dopamine group （P 〈 0.05 ）. Conclusion Norepinephrine and dopamine in the treatment of shock has similar clinical effect, but norepinephrine is more effective in the improvement of renal function compared with dopamine.
出处
《中国基层医药》
CAS
2014年第6期882-883,共2页
Chinese Journal of Primary Medicine and Pharmacy
