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Synthetic biodegradable functional polymers for tissue engineering:a brief review 被引量:19

Synthetic biodegradable functional polymers for tissue engineering:a brief review
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摘要 Scaffolds play a crucial role in tissue engineering. Biodegradable polymers with great processing flexibility are the predominant scaffolding materials. Synthetic biodegradable polymers with well-defined structure and without immunological concerns associated with naturally derived polymers are widely used in tissue engineering. The synthetic biodegradable polymers that are widely used in tissue engineering, including polyesters, polyanhydrides, polyphosphazenes, polyurethane, and poly(glycerol sebacate) are summarized in this article. New developments in conducting polymers, photoresponsive polymers, amino-acid-based polymers, enzymatically degradable polymers, and peptide-activated polymers are also discussed. In addition to chemical functionalization, the scaffold designs that mimic the nano and micro features of the extracellular matrix(ECM) are presented as well, and composite and nanocomposite scaffolds are also reviewed. Scaffolds play a crucial role in tissue engineering. Biodegradable polymers with great processing flexibility are the predomi- nant scaffolding materials. Synthetic biodegradable polymers with well-defined structure and without immunological concerns associated with naturally derived polymers are widely used in tissue engineering. The synthetic biodegradable polymers that are widely used in tissue engineering, including polyesters, polyanhydrides, polyphosphazenes, polyurethane, and poly (glyc- erol sebacate) are summarized in this article. New developments in conducting polymers, photoresponsive polymers, ami- no-acid-based polymers, enzymatically degradable polymers, and peptide-activated polymers are also discussed. In addition to chemical functionalization, the scaffold designs that mimic the nano and micro features of the extracellular matrix (ECM) are presented as well, and composite and nanocomposite scaffolds are also reviewed.
出处 《Science China Chemistry》 SCIE EI CAS 2014年第4期490-500,共11页 中国科学(化学英文版)
基金 the financial support of the US National Institutes of Health(NIDCR DE015384,DE017689,DE022327) DOD(W81XWH-12-2-0008) the National Science Foundation of the United States(DMR-1206575) the National Natural Science Foundation of China(21304073)
关键词 synthetic biodegradable polymers functional polymers scaffolds tissue engineering 可生物降解聚合物 组织工程 人工合成 功能高分子 生物可降解聚合物 聚氨基甲酸乙酯 支架设计 支架材料
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