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代谢性谷氨酸受体5参与吗啡耐受及其机制 被引量：2

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摘要 长期使用吗啡将造成吗啡耐受，表现为吗啡镇痛效应减弱，需加大药物剂量才能达到相同的效果。吗啡耐受现象大大限制了阿片类药物在临床的应用，也成为疼痛治疗中的难题。其发生机制至今仍不明确。谷氨酸是中枢神经系统一种主要的兴奋性神经递质，对脑功能整合和神经元细胞生长起重要作用。
作者 周全红 江伟
机构地区 上海交通大学附属第六人民医院麻醉科
出处 《上海医学》 CAS CSCD 北大核心 2014年第2期175-177,共3页 Shanghai Medical Journal
基金 国家自然科学基金(30972850) 上海市卫生局科学课题基金(20114222)资助项目
关键词 代谢性谷氨酸受体5 吗啡耐受 兴奋性神经递质 中枢神经系统 阿片类药物 脑功能整合 镇痛效应 药物剂量
分类号 R96 [医药卫生—药理学]
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参考文献31

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共引文献1

同被引文献34

  • 1胡优敏,董莉,孙碧英,李倩,王小芳,施渭彬,戎伟芳.促代谢型谷氨酸受体mGluR5参与膀胱的生理与伤害性感受[J].科技导报,2006,24(12):23-27. 被引量：1
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二级引证文献4

上海医学
2014年 第2期

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