摘要
镰形棘豆是中国应用的传统藏药，由于该植物的很多生物活性与其黄酮类有关，本研究提取了镰形棘豆中的总黄酮苷元，选择了9种病原菌对其抑菌活性进行了体外抑菌试验的评估。试验结果表明，镰形棘豆分离得到的总黄酮苷元对试验所用的病原菌均有较强的抑菌作用，其中对金黄色葡萄球菌的最低抑菌浓度为MIC=0．38mg／mL，其他各菌的MIC和MBC范围在0．75～3mg／mL之间。通过此研究可为镰形棘豆黄酮类活性组分的进一步研究提供依据。
Oxytropis falcate Bunge （O.falcata） is a traditional Tibetan medicine of China. Since its various bioactivity is based on the presence of flavonoids, we extracted the total flavonoid aglycones （TFA） of O.falcata and investigated its antibacterial activity in view of 9 kinds of pathogenic bacteria. The results showed that the minimal inhibitory concentration （MIC） of TFA against Staphylococcus aureus was 0.38 mg/mL,which was the lowest. Against the other tested bacteria, the MIC and MBC values were between 0.75 and 3 mg/mL. This study provided evidence of the antibacterial activity of TFA and lay foundation for the further research of the flavonoids in O.falcata.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2014年第3期407-409,383,共4页
Natural Product Research and Development
基金
supported by the National ScienceFoundation(81260633)
The Research Fund of Chinese Academy ofSciences(KGCX2-SW-213-08)
关键词
总黄酮苷元
镰形棘豆
抑菌活性
total flavonoid aglycones
Oxytropis falcata Bunge
antibacterial activity
