摘要
目的:观察肺炎合剂在治疗小儿细菌性肺炎中的疗效及对血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)的影响。方法:将确诊为细菌性肺炎的病例106例,应用随机数字表法分为对照组56例与治疗组50例。其中,对照组进行常规抗感染、雾化对症治疗,有缺氧表现者给予吸氧支持;治疗组在对照组基础上加服肺炎合剂治疗。两组疗程均为7 d。观察两组患儿的临床疗效、实验室检查指标及不良反应。结果:治疗组在咳嗽好转、气喘消失、肺部啰音消失及体温恢复正常时间方面均优于对照组,差异有统计学意义(P<0.01或P<0.05);治疗组总有效率高于对照组,差异有统计学意义(P<0.05);治疗组患儿血清PCT、hs-CRP、WBC下降明显,与对照组比较差异有统计学意义(P<0.05)。治疗组有1例患儿出现呕吐,1例患儿出现轻度腹泻,无其他副作用。结论:肺炎合剂在抑制机体炎症反应过程中有一定作用,可作为临床小儿肺炎的辅佐治疗药物。
OBJECTIVE： To observe the effects of Pneumonia mixture on the serum levels of PCT, hs-CRP and WBC in children with bacterial pneumonia. METHODS： 106 children diagnosed as bacterial pneumonia were randomly divided into control group （56 cases） and treatment group （50 cases）. Control group received conventional anti-infective and atomization symptomatic treatment, and hypoxia patients were given oxygen support; treatment group was additionally given Pneumonia mixture orally for 7 days on the basis of control group. Clinical efficacies, laboratory index and ADR were observed in 2 groups. RESULTS ： The im- provement of cough, asthma disappearance, pulmonary rales disappearance and body temperature recovery in treatment group were all better than in control group; there was statistical significance （P〈0.01 or P〈0.05）. The total effective rate of treatment group was higher that of control group; there was statistical significance （P〈0.05） ; the levels of PCT, hs-CRP and WBC in serum de- creased significantly in treatment group; there was statistical significance（P〈0.05）. In treatment group, a child suffered from vom- iting in children, and another child suffered from mild diarrhea; no other side effects were found. CONCLUSIONS： Pneumonia mixture can inhibit inflammatory reaction, and can be used for assistant therapy for infantile pneumonia in the clinic.
出处
《中国药房》
CAS
CSCD
2014年第15期1416-1418,共3页
China Pharmacy
