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阿维菌素-羟丙基-β-环糊精包合物的制备 被引量:5

Peparation of avermectin/hydroxypropyl-β-cyclodextrin inclusion compound
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摘要 对羟丙基-β-环糊精包合阿维菌素进行了研究.通过应用溶液搅拌法制取包合物,采用单因素试验和正交试验确定的最佳工艺条件为:主客体投料质量比为100∶3,包合温度为50℃,包合时间为8h.在最佳工艺条件下,用HPLC法确定包合率为39.6%,用称重法确定收率为81.1%,并对包合物做了TG分析.结果表明:被包合后的阿维菌素的水溶性、光稳定性显著提高,同时提高了阿维菌素杀虫杀螨的长效性. Avermectin entrapped in HP-β-cyclodextrin was investigated.The water was selected as medium to prepare the inclusion compound.Employing single factor and orthogonal tests,the best conditions of inclusion process were determined as follows:the feeding quality ratio being 100 ∶ 3,inclusion temperature at 50 ℃,inclusion time for 8 h.Under these conditions,it was determined by HPLC that the inclusion efficiency was 39.6%,and the yield was 81.1%.The inclusion compound was analysed by TG.The results show that the light stability and solubility in water of avermectin entrapped in HP-β-cyclodextrin increase significantly compared with avermectin.The long-term performance of avermectin's insecticidal and acaricidal properties are improved significantly.
出处 《陕西师范大学学报(自然科学版)》 CAS CSCD 北大核心 2014年第2期50-54,共5页 Journal of Shaanxi Normal University:Natural Science Edition
基金 国家自然科学基金资助项目(21144008) 陕西省自然科学基金资助项目(2011JM2005)
关键词 阿维菌素 HP-β-环糊精 包合 avermectin HP-β-cyclodextrin inclusion
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